128430-66-0Relevant articles and documents
Preparation method of lansoprazole key intermediate
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Paragraph 0033; 0036; 0037; 0040; 0041; 0044; 0045; 0048, (2020/07/13)
The invention relates to a preparation method of a lansoprazole key intermediate. According to the technical scheme, the preparation method comprises the following steps: firstly, respectively preparing (2, 2, 2-trifluoroethoxy)ethylene (a compound 7) and 3-amino-4-chloro-2-methylbut-2-enoic acid ethyl ester (a compound 9); and then reacting the compound 7 with the compound 9 to prepare 6-(chloromethyl)-5-methyl-4-(2, 2, 2-trifluoroethoxy)-2,3,4,5- tetrahydropyridine; finally, oxidizing 6-(chloromethyl)-5-methyl-4-(2, 2, 2-trifluoroethoxy)-2, 3, 4, 5-tetrahydropyridine (compound 10) by hydrogen peroxide under the catalytic action of Mn(O)-Salon to generate 2-(chloromethyl)-3-methyl-4-(2, 2, 2-trifluoroethoxy)pyridine (compound 5). According to the technical scheme, danger is reduced, energy consumption is reduced, and the method is more suitable for large-scale industrial production.
A practical one pot synthesis of 2-[2-(pridylmethyl)-thio]-1H-benzimidazoles
Rane,Pathak,Kaushik,Prasad Rao,Kumar, Ashok
, p. 1211 - 1217 (2007/10/03)
A combination of Et3N and pTSCl was found to be far superior than pTSCl or benzene sulfonyl chloride alone in convert ing substituted 2-picoline-N-oxides to the corresponding 2-chloromethylpyridines and has been exploited for the synthesis of a variety of 2-[2-(pyridylmethyl)-thio]-1H-benzimidazoles, key intermediates in the manufacture of H+/K+-ATPase inhibitors in a single pot.