1285527-53-8

Basic information

• Product Name: butyl 2-cyano-3-hydroxyurs-12-en-24-oate
• Synonyms: butyl 2-cyano-3-hydroxyurs-12-en-24-oate
• CAS NO: 1285527-53-8
• Molecular Weight: 537.827
• Mol File: 1285527-53-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: butyl 2-cyano-3-hydroxyurs-12-en-24-oate(CAS DataBase Reference)
• NIST Chemistry Reference: butyl 2-cyano-3-hydroxyurs-12-en-24-oate(1285527-53-8)
• EPA Substance Registry System: butyl 2-cyano-3-hydroxyurs-12-en-24-oate(1285527-53-8)

Safety Data

• Hazardous Substances Data: 1285527-53-8(Hazardous Substances Data)

Upstream product

• 5968-70-7 3-O-acetyl-β-boswellic acid 

Relevant articles and documents

A comparative study of proapoptotic potential of cyano analogues of boswellic acid and 11-keto-boswellic acid

Semi-synthetic analogues of β-boswellic acid (BA) and 11-keto-β-boswellic acid (KBA) were comparatively evaluated for in vitro cytotoxicity against human myeloid leukaemia (HL-60) and human cervical carcinoma (HeLa) cells. 2-Cyano analogues of both the triterpenes were observed to have significant cytotoxicity against both the cells, displaying cytotoxicity in HL-60 cells at low concentrations. Further investigations suggested the proapoptotic potential associated with the two molecules to induce cytotoxicity in HL-60 cells, where one of them showed early proapoptotic effect as evidenced by several biological end-points of the apoptosis such as annexinV binding, DNA fragmentation and increase in sub-G0 DNA fraction and apoptotic bodies formation (Hoechst 33258 staining and SEM studies).