128562-25-4

Basic information

• Product Name: 4-Pyrrolidin-2-ylpyridine
• Synonyms: 4-PYRROLIDIN-2-YLPYRIDINE;4-(2-PYRROLIDINYL)PYRIDINE;2-(4-PYRIDYL)PYRROLIDINE;4-(2-Pyridyl)pyrrolidine;2-(Pyridin-4-yl)pyrrolidine;2-(4-Pyridinyl)pyrrolidine;Pyridine, 4-(2-pyrrolidinyl)-;4-(pyrrolidin-2-yl)pyridine dihydrochloride
• CAS NO: 128562-25-4
• Molecular Formula: C9H12N2
• Molecular Weight: 148.2
• Product Categories: PYRIDINE;Benzenes;Aromatics;Heterocycles;Heterocycle-Pyridine series
• Mol File: 128562-25-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 253.81 °C at 760 mmHg
• Flash Point: 107.301 °C
• Appearance: /
• Density: 1.043 g/cm³
• Vapor Pressure: 0.0179mmHg at 25°C
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 8.84±0.10(Predicted)
• Water Solubility: Slightly soluble in water.
• CAS DataBase Reference: 4-Pyrrolidin-2-ylpyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Pyrrolidin-2-ylpyridine(128562-25-4)
• EPA Substance Registry System: 4-Pyrrolidin-2-ylpyridine(128562-25-4)

Safety Data

• Hazard Codes: Xi,T
• Statements: 25
• Safety Statements: 45
• HazardClass: IRRITANT
• Hazardous Substances Data: 128562-25-4(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 128562-25-4 differently. You can refer to the following data:
1. 4-Pyrrolidin-2-ylpyridine can be used in aldol catatlysis, in the preparation of azole compounds as 11β-HSD1 inhibitors as well as in the asymetric synthesis of pyrazolodihydropyrimidinylpyrrolidin amide derivatives.
2. 4-(2-Pyrrolidinyl)-pyridine can be used in aldol catatlysis, in the preparation of azole compounds as 11β-HSD1 inhibitors as well as in the asymetric synthesis of pyrazolodihydropyrimidinylpyrrolidin amide derivatives.

InChI:InChI=1/C9H12N2/c1-2-9(11-5-1)8-3-6-10-7-4-8/h3-4,6-7,9,11H,1-2,5H2/p+1/t9-/m1/s1

Upstream product

• 1570-45-2 isonicotinic acid ethylester 
• 66269-78-1 4-(3,4-dihydro-2H-pyrrol-5-yl)pyridine 

Downstream Products

• 343244-28-0 1-[[7-(3,4-Dichloro-phenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-2-(4-pyridinyl)pyrrolidine 

Relevant articles and documents

Pyrrolidine amides of pyrazolodihydropyrimidines as potent and selective KV1.5 blockers

Design and synthesis of pyrazolodihydropyrimidines as KV1.5 blockers led to the discovery of 7d as a potent and selective antagonist. This compound showed atrial selective prolongation of effective refractory period in rabbits and was selected for clinical development.

Aqueous aldol catalysis by a nicotine metabolite

Nornicotine, an endogenous tobacco alkaloid and minor nicotine metabolite, can catalyze aldol reactions at physiological pH. Catalysis appears to be due to a covalent enamine mechanism, an unprecedented reaction with small organic molecule catalysts in aqueous buffer. Kinetic parameters for nornicotine as well as other related alkaloids were measured and demonstrate that both the pyrrolidine and pyridine rings are critical for optimal catalysis. Substrate compatibility of this catalyst and its implications in vivo are discussed. Copyright