128562-95-8

Basic information

• Product Name: 4-(TRIFLUOROMETHYL)-1H-INDOLE
• Synonyms: 4-(TRIFLUOROMETHYL)-1H-INDOLE;4-(Trifluoromethyl)-indole;1H-Indole, 4-(trifluoroMethyl)-
• CAS NO: 128562-95-8
• Molecular Formula: C₉H₆F₃N
• Molecular Weight: 185.15
• Mol File: 128562-95-8.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 256.7±35.0℃ (760 Torr)
• Flash Point: 109.0±25.9℃
• Appearance: /Solid
• Density: 1.367±0.06 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 0.0244mmHg at 25°C
• Refractive Index: 1.555
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 15.59±0.30(Predicted)
• CAS DataBase Reference: 4-(TRIFLUOROMETHYL)-1H-INDOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(TRIFLUOROMETHYL)-1H-INDOLE(128562-95-8)
• EPA Substance Registry System: 4-(TRIFLUOROMETHYL)-1H-INDOLE(128562-95-8)

Safety Data

• Hazardous Substances Data: 128562-95-8(Hazardous Substances Data)

Usage

General Description

4-(Trifluoromethyl)-1H-indole is a chemical compound with the molecular formula C9H6F3N. It is a fluorinated indole derivative commonly used in medicinal and pharmaceutical research. 4-(TRIFLUOROMETHYL)-1H-INDOLE is known to exhibit various biological activities, including anti-inflammatory and anti-cancer properties, making it a valuable candidate for drug development. Its unique chemical structure and fluorine substitution make it ideal for modulating the activity of biological targets, and it has been studied for its potential therapeutic applications in various diseases. Additionally, its trifluoromethyl group contributes to the compound's overall stability and lipophilicity, making it a versatile building block for the synthesis of complex molecules.

InChI:InChI=1/C9H6F3N/c10-9(11,12)7-2-1-3-8-6(7)4-5-13-8/h1-5,13H

Upstream product

• 905274-06-8 dimethyl[(E)-2-(2-nitro-6-trifluoromethylphenyl)vinyl]amine 
• 6656-49-1 2-methyl-1-nitro-3-(trifluoromethyl)benzene 

Downstream Products

• 1018974-87-2 1-benzenesulfonyl-4-trifluoromethyl-1H-indole 
• 1018974-88-3 1-benzenesulfonyl-2-methyl-4-trifluoromethyl-1H-indole 
• 1313040-69-5 [4-(5-aminomethyl-2-fluoro-phenyl)-piperidin-1-yl]-[1-(2-methoxy-ethyl)-4-trifluoromethyl-1H-indol-3-yl]-methanone hydrochloride 
• 1313043-33-2 2,2,2-trifluoro-N-(4-fluoro-3-{1-[1-(2-methoxy-ethyl)-4-trifluoromethyl-1H-indole-3-carbonyl]-piperidin-4-yl}-benzyl)-acetamide 
• 1313043-31-0 2,2,2-trifluoro-1-(1-(2-methoxyethyl)-4-(trifluoromethyl)-1H-indol-3-yl)ethanone 

Relevant articles and documents

A indole compound and its preparation method and application (by machine translation)

The invention discloses a indole compound and its preparation method and application. The indole compounds of the structural formula such as formula (I) is shown. The indoles, rice galenical demonstrate the excellent inhibitory activity, the effect of most of the compound is obviously better than the positive control drug validamycin; especially compound I - 43, I - 44, I - 54, I - 73, II - 7 and II - 17, its galenical very good living body protection and treating effect, effect is better than the positive control; more specifically, compound I - 43 of the rice sheath blight bacteriostatic activity than validamycin activity is improved by nearly 300 times. The indole compounds in the prevention and/or treatment of rice sheath blight has great application prospects. In addition the compound of the invention is simple in construction, the preparation method is simple, and is suitable for large-scale industrial production. (I). (by machine translation)

HETEROCYCLIC COMPOUNDS AS ANTIBIOTIC POTENTIATORS

The invention relates to heterocyclic compounds and their use as antibiotics and/or as antibiotic potentiators. The compounds may act as colistin potentiators and SOS inhibitors.

INDOLE SULFONAMIDES AS SFRP-1 MODULATORS

Indole sulfonamide compounds or pharmaceutically acceptable salts thereof, are provided, which are modulators of secreted frizzled related protein-1. The compounds, and compositions containing the compounds, can be used to treat a variety of disorders, in