1286209-74-2

Basic information

• Product Name: 10-(2,3,4-trimethoxy-6-methylphenyl)decan-1-ol
• Synonyms: 10-(2,3,4-trimethoxy-6-methylphenyl)decan-1-ol
• CAS NO: 1286209-74-2
• Molecular Weight: 338.488
• Mol File: 1286209-74-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 10-(2,3,4-trimethoxy-6-methylphenyl)decan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 10-(2,3,4-trimethoxy-6-methylphenyl)decan-1-ol(1286209-74-2)
• EPA Substance Registry System: 10-(2,3,4-trimethoxy-6-methylphenyl)decan-1-ol(1286209-74-2)

Safety Data

• Hazardous Substances Data: 1286209-74-2(Hazardous Substances Data)

Upstream product

• 112-47-0 1,10-Decanediol 
• 53463-68-6 1-bromo-10-decanol 
• 13019-22-2 9-Decen-1-ol 
• 72326-72-8 2-bromo-3,4,5-trimethoxy-1-methylbenzene 
• 6443-69-2 3,4,5-trimethoxytoluene 

Downstream Products

• 58186-27-9 Idebenone 
• 58186-28-0 2,3-dimethoxy-5-methyl-6-(10'-acetoxydecyl)-1,4-benzoquinone 
• 1286209-75-3 10-(2,3,4-trimethoxy-6-methylphenyl)decyl acetate 

Relevant articles and documents

Synthetic route discovery and introductory optimization of a novel process to idebenone

An environmentally benign, convenient, high yielding, and cost-effective synthesis leading to idebenone is disclosed. The synthesis includes a bromination process for the preparation of 2-bromo-3,4,5-trimethoxy-1- methylbenzene, a protocol for the Heck cross-coupling reaction using either thermal or microwave heating, olefin reduction by palladium catalyzed hydrogenation, and a green oxidation protocol with hydrogen peroxide as oxidant to achieve the benzoquinone framework. The total synthesis is composed of six steps that provide an overall yield of 20% that corresponds to a step yield of 76%.