128668-89-3

Basic information

• Product Name: cis-3-phenyl-1,2,3,4a,5,6,7,7a-octahydrocyclopentapyrimidine-2,4-dione
• CAS NO: 128668-89-3
• Molecular Weight: 230.266
• Mol File: 128668-89-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: cis-3-phenyl-1,2,3,4a,5,6,7,7a-octahydrocyclopentapyrimidine-2,4-dione(CAS DataBase Reference)
• NIST Chemistry Reference: cis-3-phenyl-1,2,3,4a,5,6,7,7a-octahydrocyclopentapyrimidine-2,4-dione(128668-89-3)
• EPA Substance Registry System: cis-3-phenyl-1,2,3,4a,5,6,7,7a-octahydrocyclopentapyrimidine-2,4-dione(128668-89-3)

Safety Data

• Hazardous Substances Data: 128668-89-3(Hazardous Substances Data)

Upstream product

• 129169-58-0 (1R,2S)-2-Amino-cyclopentanecarboxylic acid phenylamide 
• 125910-62-5 (1S,5R)-7-Oxo-6-aza-bicyclo[3.2.0]heptane-6-carboxylic acid phenylamide 
• 142-29-0 cyclopentene 
• 62-53-3 aniline 
• 103-71-9 phenyl isocyanate 
• 22031-52-3 cis-2-aza-3-oxobicyclo<3.2.0>heptane 
• 57043-00-2 (1RS,2SR)-cispentacin 
• 38052-23-2 ethyl cis-2-amino-1-cyclopentane-carboxylate 

Relevant articles and documents

Saturated Heterocyles, 248. Synthesis of 2,4-Dioxo and 4-Oxo-2-thioxo Derivatives of Octahydrocyclopentapyrimidines

Unsubstituted and 1-benzyl-substituted cis-cyclopentapyrimidine-2,4-diones and cis-2-thioxocyclopentapyrimidin-4-ones 9a,b and 10a,b were prepared from the corresponding cis-2-amino-1-cyclopentanecarboxylates 3 and 5 with potassium cyanate and thiocyanate.It was found that the cis-derivatives 7a-h readily underwent ring closure, resulting in 3-substituted cis-2,4-cyclopentapyrimidinediones and cis-2-thioxocyclopentapyrimidin-4-ones 11a-d and 12a-d, whereas the trans counterparts 8a-d failed to cyclize, but gave hydrolyzed amino acid derivatives 13a,b and 14.This difference in the reactivities of the cis and trans isomers is a further example of the difficulty of preparing cyclopentane trans-fused six-membered 1,3-heterocycles by ring closure.