1287715-55-2

Basic information

• Product Name: (+)-5'-(3-chlorophenyl)-1,5,5'-trimethyl-2'-thioxospiro[indoline-3,4'-oxazolidin]-2-one
• CAS NO: 1287715-55-2
• Molecular Weight: 400.501
• Mol File: 1287715-55-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (+)-5'-(3-chlorophenyl)-1,5,5'-trimethyl-2'-thioxospiro[indoline-3,4'-oxazolidin]-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (+)-5'-(3-chlorophenyl)-1,5,5'-trimethyl-2'-thioxospiro[indoline-3,4'-oxazolidin]-2-one(1287715-55-2)
• EPA Substance Registry System: (+)-5'-(3-chlorophenyl)-1,5,5'-trimethyl-2'-thioxospiro[indoline-3,4'-oxazolidin]-2-one(1287715-55-2)

Safety Data

• Hazardous Substances Data: 1287715-55-2(Hazardous Substances Data)

Upstream product

• 1324055-93-7 3-amino-1-benzylindolin-2-one hydrochloride 
• 1025736-33-7 C₁₅H₁₄N₂O 
• 1287715-31-4 1-benzyl-3-isothiocyanatoindolin-2-one 
• 98-86-2 acetophenone 
• 28150-91-6 1-benzyl-3-(hydroxyimino)indolin-2-one 

Relevant articles and documents

Organocatalytic direct asymmetric aldol reactions of 3-isothiocyanato oxindoles to ketones: Stereocontrolled synthesis of spirooxindoles bearing highly congested contiguous tetrasubstituted stereocenters

Chemical equations presented. The first example of a direct catalytic asymmetric intermolecular aldol reaction of 3-isothiocyanato oxindoles to simple ketones with bifunctional thiourea-tertiary amine as catalyst is reported. This strategy provides a promising approach for the asymmetric synthesis of a range of enantioenriched spirocyclic oxindoles bearing two highly congested contiguous tetrasubstituted carbon stereocenters. Versatile transformations of the spirocyclic oxindole products into other structurally diverse spirocyclic oxindoles have also been demonstrated.