129095-27-8Relevant articles and documents
Synthesis and Hypocholesterolemic Activity of 6,7-Dihydro-4H-pyrazolopyrrolopyrimidine-5,8-diones, Novel Inhibitors of AcylCoA:Cholesterol O-Acyltransferase
Larsen, Scott D.,Spilman, Charles H.,Bell, Frank P.,Dinh, Dac M.,Martinborough, Esther,Wilson, Gracella J.
, p. 1721 - 1727 (2007/10/02)
A novel series of 6,7-dihydro-4H-pyrazolopyrrolopyrimidine-5,8-dione inhibitors of the enzyme acylCoA:cholesterol O-acyltransferase is described.A number of these derivatives were found to be potent modulators of serum lipoprotein levels in