129225-67-8

Basic information

• Product Name: Benzenesulfenyl chloride, 2,6-dimethyl-
• CAS NO: 129225-67-8
• Molecular Formula: C8H9ClS
• Molecular Weight: 172.678
• Mol File: 129225-67-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Benzenesulfenyl chloride, 2,6-dimethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenesulfenyl chloride, 2,6-dimethyl-(129225-67-8)
• EPA Substance Registry System: Benzenesulfenyl chloride, 2,6-dimethyl-(129225-67-8)

Safety Data

• Hazardous Substances Data: 129225-67-8(Hazardous Substances Data)

Upstream product

• 94764-21-3 Thioessigsaeure-<2,6-dimethyl-phenyl>-ester 
• 118-72-9 2,6-dimethylbenzene-1-thiol 

Downstream Products

• 2905-17-1 bis(2,6-dimethylphenyl)disulfide 
• 1054598-71-8 3-[2-(2,6-dimethyl-phenylsulfanyl)-1H-indol-3-yl]-propionic acid methyl ester 
• 1054599-33-5 dimethyl ((2-[(2,6-dimethylphenyl)thio]-1H-indol-3-yl)methyl)malonate 
• 1054598-83-2 tert-butyl (2-(2-[(2,6-dimethylphenyl)thio]-1H-indol-3-yl)ethyl)carbamate 
• 54088-93-6 2,6-dimethylphenyl phenyl sulfide 

Relevant articles and documents

Diaryl and heteroaryl sulfides: Synthesis via sulfenyl chlorides and evaluation as selective anti-breast-cancer agents

A mild protocol for the synthesis of diaryl and heteroaryl sulfides is described. In a one-pot procedure, thiols are converted to sulfenyl chlorides and reacted with arylzinc reagents. This method tolerates functional groups including aryl fluorides and chlorides, ketones, as well as N-heterocycles including pyrimidines, imidazoles, tetrazoles, and oxadiazoles. Two compounds synthesized by this method exhibited selective activity against the MCF-7 breast cancer cell line in the micromolar range.