129339-72-6

Basic information

• Product Name: 1-Benzoyl-4-methyl-1H-pyrrole-2-carboxylic acid methyl ester
• Synonyms: 1-Benzoyl-4-methyl-1H-pyrrole-2-carboxylic acid methyl ester
• CAS NO: 129339-72-6
• Molecular Weight: 243.262
• Mol File: 129339-72-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-Benzoyl-4-methyl-1H-pyrrole-2-carboxylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Benzoyl-4-methyl-1H-pyrrole-2-carboxylic acid methyl ester(129339-72-6)
• EPA Substance Registry System: 1-Benzoyl-4-methyl-1H-pyrrole-2-carboxylic acid methyl ester(129339-72-6)

Safety Data

• Hazardous Substances Data: 129339-72-6(Hazardous Substances Data)

Upstream product

• 129339-66-8 methyl 2-benzoylamino-5-ethoxy-4-methylpenta-2,4-dienoate 
• 129339-65-7 4-(3-ethoxy-2-methylallylidene)-2-phenyloxazol-5(4H)-one 
• 129339-64-6 4-(3-hydroxy-2-methylallylidene)-2-phenyloxazol-5(4H)-one 
• 495-69-2 Hippuric Acid 

Downstream Products

• 18711-59-6 4-methyl-1H-pyrrole-2-carboxylic acid 
• 93-58-3 benzoic acid methyl ester 
• 34402-78-3 methyl 4-methyl-1H-pyrrole-2-carboxylate 

Relevant articles and documents

Syntheses of 3-Methylpyrrole via Methyl 4-Methylpyrrole-2-carboxylate: A Thermal Oxazolone-Pyrone Rearrangement

3-Ethoxy-2-methylpropenal with hippuric acid and acetic anhydride gave 4-(3-ethoxy-2-methylallylidene)-2-phenyloxazol-5(4H)-one.By successive treatment with methanolic potassium hydroxide, acetic-hydrochloric acid, and methanolic sodium methoxide, methyl 4-methylpyrrole-2-carboxylate was formed in high overall yield, and was converted into 3-methylpyrrole by hydrolysis and decarboxylation.The oxazolone with sodium hydroxide in acetone or dioxane gave 4-(3-hydroxy-2-methylallyilidene)-2-phenyloxazol-5(4H)-one, isomerized in boiling acetone, or on melting, to 3-benzoylamino-5-methylpyran-2-one. 3-Ethoxy-2-methylpropenal condensed with glycine methyl ester to give an enaminal, cyclized in moderate yield to methyl 4-methylpyrrole-2-carboxylate.