1296137-06-8

Basic information

• Product Name: (E)-N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(1-(4-hydroxy-3-(hydroxymethyl)butyl)-1H-indol-3-yl)acrylamide
• Synonyms: (E)-N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(1-(4-hydroxy-3-(hydroxymethyl)butyl)-1H-indol-3-yl)acrylamide
• CAS NO: 1296137-06-8
• Molecular Weight: 531.695
• Mol File: 1296137-06-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (E)-N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(1-(4-hydroxy-3-(hydroxymethyl)butyl)-1H-indol-3-yl)acrylamide(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(1-(4-hydroxy-3-(hydroxymethyl)butyl)-1H-indol-3-yl)acrylamide(1296137-06-8)
• EPA Substance Registry System: (E)-N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(1-(4-hydroxy-3-(hydroxymethyl)butyl)-1H-indol-3-yl)acrylamide(1296137-06-8)

Safety Data

• Hazardous Substances Data: 1296137-06-8(Hazardous Substances Data)

Upstream product

• 102147-75-1 2,2-dimethyl-5-(2'-hydroxyethyl)-1,3-dioxane 
• 6482-32-2 2-(hydroxymethyl)butane-1,4-diol 
• 7459-46-3 triethyl 1,1,2-ethanetricarboxylate 
• 1296137-00-2 C₂₇H₃₁N₃O₂ 
• 127218-58-0 2-(2,2-dimethyl-1,3-dioxan-5-yl)ethyl 4-methylbenzenesulfonate 
• 1296137-14-8 2-{4-[1-(phenylcarbonyl)piperidin-4-yl]butyl}-1H-isoindole-1,3(2H)-dione 
• 1296137-13-7 C₁₇H₂₅NO₄S 
• 1041756-51-7 C₁₆H₂₃NO₂ 
• 1296136-93-0 methyl 4-(1-benzoylpiperidin-4-yl)butanoate 
• 1041756-57-3 [4-(4-aminobutyl)-1-piperidinyl](phenyl)methenone 
• 408538-69-2 4-piperidin-4-ylbutyric acid methyl ester 

Relevant articles and documents

Design, synthesis and X-ray crystallographic study of NAmPRTase inhibitors as anti-cancer agents

NAmPRTase (PBEF/Visfatin) plays a pivotal role in the salvage pathway of NAD+ biosynthesis. NAmPRTase has been an attractive target for anti-cancer agents that induce apoptosis of tumor cells via a declining plasma NAD+ level. In this report, a series of structural analogs of FK866 (1), a known NAmPRTase inhibitor, was synthesized and tested for inhibitory activities against the proliferation of cancer cells and human NAmPRTase. Among them, compound 7 showed similar anti-cancer and enzyme inhibitory activities to compound 1. Further investigation of compound 7 with X-ray analysis revealed a co-crystal structure in complex with human NAmPRTase, suggesting that Asp219 in the active site of the enzyme could contribute to an additional interaction with the pyrrole nitrogen of compound 7.