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1300-94-3

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1300-94-3 Usage

Description

5-METHYL-2-N-PENTYLPHENOL, also known as Amylmetacresol, is a phenol derivative with the structure of m-cresol substituted at the 6-position with an amyl group. It is a clear or almost clear liquid, or a solid crystalline mass, which is colorless or slightly yellow when freshly prepared. The substance may change color during storage, darkening or discoloring to shades of dark yellow, brownish-yellow, or pink. It has a role as an antiseptic drug and is derived from m-cresol.

Uses

Used in Pharmaceutical Industry:
5-METHYL-2-N-PENTYLPHENOL is used as an antiseptic for the treatment of sore throat and minor mouth infections. It is particularly effective in managing acute sore throat (pharyngitis), a common condition in children. The compound is often combined with dichlorobenzyl alcohol and menthol in over-the-counter throat lozenges, such as Strepsils, which offer rapid and effective relief of acute sore throat symptoms.
Used in Antimicrobial Applications:
In the field of antimicrobials, 5-METHYL-2-N-PENTYLPHENOL serves as an active ingredient in various products designed to combat infections. Its antiseptic properties make it a valuable component in the development of new treatments and preventive measures against bacterial and fungal infections.
Used in Cosmetics and Personal Care Industry:
5-METHYL-2-N-PENTYLPHENOL can also be utilized in the cosmetics and personal care industry as an ingredient in products that require antimicrobial properties. Its ability to inhibit the growth of microorganisms makes it suitable for inclusion in formulations for skincare, hair care, and oral hygiene products.
Used in Veterinary Medicine:
In veterinary medicine, 5-METHYL-2-N-PENTYLPHENOL can be employed as an antiseptic to treat various animal health conditions, such as skin infections, wounds, and oral health issues. Its broad-spectrum antimicrobial activity makes it a valuable asset in the veterinary field.
Used in Research and Development:
5-METHYL-2-N-PENTYLPHENOL is also used in research and development for the discovery of new pharmaceutical compounds and applications. Its unique chemical structure and antiseptic properties make it an interesting candidate for further study and potential development of novel therapeutic agents.

Mode of action

The mechanism of virucidal action is not fully elucidated, however it is suggested that denaturation of external protein spikes, a pH-induced rearrangement of the tertiary structure of attachment proteins, or a selective effect on viral lipid membranes/protein–lipid interaction is responsible for this action. Amylmetacresol is an antibacterial and antiviral agent, and blocks voltage-gated Na channels in a local anesthetic-like manner.

Check Digit Verification of cas no

The CAS Registry Mumber 1300-94-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,3,0 and 0 respectively; the second part has 2 digits, 9 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1300-94:
(6*1)+(5*3)+(4*0)+(3*0)+(2*9)+(1*4)=43
43 % 10 = 3
So 1300-94-3 is a valid CAS Registry Number.
InChI:InChI=1/C12H18O/c1-3-4-5-6-11-8-7-10(2)9-12(11)13/h7-9,13H,3-6H2,1-2H3

1300-94-3 Well-known Company Product Price

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  • Sigma-Aldrich

  • (Y0001244)  Amylmetacresol  European Pharmacopoeia (EP) Reference Standard

  • 1300-94-3

  • Y0001244

  • 1,880.19CNY

  • Detail
  • Sigma-Aldrich

  • (Y0001245)  Amylmetacresol for peak identification  European Pharmacopoeia (EP) Reference Standard

  • 1300-94-3

  • Y0001245

  • 1,880.19CNY

  • Detail

1300-94-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name amylmetacresol

1.2 Other means of identification

Product number -
Other names 5-METHYL-2-N-PENTYLPHENOL

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1300-94-3 SDS

1300-94-3Synthetic route

1-<2-hydroxy-4-methyl-phenyl>-pentanone-(1)

1-<2-hydroxy-4-methyl-phenyl>-pentanone-(1)

5-methyl-2-pentylphenol
1300-94-3

5-methyl-2-pentylphenol

Conditions
ConditionsYield
With hydrogenchloride; amalgamated zinc
n-valeryl chloride
638-29-9

n-valeryl chloride

3-methyl-phenol
108-39-4

3-methyl-phenol

5-methyl-2-pentylphenol
1300-94-3

5-methyl-2-pentylphenol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: 2 h / 35 - 80 °C
1.2: 7 h / 110 °C
2.1: hydrogen; citric acid / 5%-palladium/activated carbon / isopropyl alcohol / 16 h / 12.5 °C / 525.05 Torr
View Scheme
pentanoic anhydride
2082-59-9

pentanoic anhydride

3-methyl-phenol
108-39-4

3-methyl-phenol

5-methyl-2-pentylphenol
1300-94-3

5-methyl-2-pentylphenol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: 1.5 h / 35 - 80 °C
1.2: 7 h / 110 °C
2.1: hydrogen; citric acid / 5%-palladium/activated carbon / isopropyl alcohol / 16 h / 12.5 °C / 525.05 Torr
View Scheme
1-(2-hydroxy-4-methyl-phenyl)-pentan-1-one
173851-66-6

1-(2-hydroxy-4-methyl-phenyl)-pentan-1-one

5-methyl-2-pentylphenol
1300-94-3

5-methyl-2-pentylphenol

Conditions
ConditionsYield
With hydrogen; citric acid; 5%-palladium/activated carbon In isopropyl alcohol at 12.5℃; under 525.053 Torr; for 16h; Product distribution / selectivity;
5-methyl-2-pentylphenol
1300-94-3

5-methyl-2-pentylphenol

salicylic acid
69-72-7

salicylic acid

salicylic acid-(5-methyl-2-pentyl-phenyl ester)

salicylic acid-(5-methyl-2-pentyl-phenyl ester)

Conditions
ConditionsYield
With toluene; trichlorophosphate

1300-94-3Downstream Products

1300-94-3Relevant articles and documents

EFFICIENT AND COST-EFFECTIVE PROCESS FOR THE MANUFACTURE OF AMYL M-CRESOL

-

Page/Page column 32; 36, (2012/02/15)

There is described a process for the preparation of amyl-m-cresol (AMC) which comprises the steps of; (i) reaction of m-cresol with valeric acid, or a derivative thereof, (to form m- cresol valerate (3-toluoyl valerate)); (ii) rearrangement, optionally in situ, of 3-toluoyl valerate in the presence of an oxoacid, provided that the oxoacid is not a carboxylic acid or nitric acid; and (iii) reduction of valeryl m-cresol (VMC), e.g. using a palladium on charcoal catalyst and hydrogen.

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