130052-47-0Relevant articles and documents
Regio- and stereoselective incorporation of a13C nuclide into D-ribo-phytosphingosine via SmI2-mediated C-C formation with13C-labeled isocyanide
Murakami, Masahiro,Ito, Hajime,Ito, Yoshihiko
, p. 185 - 186 (2007/10/03)
Preparation of a 13C-labeled isocyanide and its application to the total synthesis of [2-13C]D-ribo-C18-phytosphingosine are described. The synthesis of the labeled phytosphingosine is based on the use of the isocyanide as a 13CH-NH2 precursor in the SmI2-mediated three-component coupling reaction, wherein regio- and stereoselective incorporation of a 13C nuclide in the carbon skeleton is achieved.