130203-22-4

Basic information

• Product Name: PhTX-343-L-arginin-amide
• Synonyms: PhTX-343-L-arginin-amide
• CAS NO: 130203-22-4
• Molecular Weight: 591.798
• Mol File: 130203-22-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: PhTX-343-L-arginin-amide(CAS DataBase Reference)
• NIST Chemistry Reference: PhTX-343-L-arginin-amide(130203-22-4)
• EPA Substance Registry System: PhTX-343-L-arginin-amide(130203-22-4)

Safety Data

• Hazardous Substances Data: 130203-22-4(Hazardous Substances Data)

Upstream product

• 181524-53-8 (S)-2-Amino-3-(4-benzyloxy-phenyl)-propionic acid 4-nitro-phenyl ester 
• 13512-59-9 N-(tert-butyloxycarbonyl)-O-(phenylmethyl)-L-tyrosine 4-nitrophenol ester 
• 2130-96-3 O-benzyl-N-tert-butoxycarbonyl-L-tyrosine 
• 852395-08-5 [3-({4-[(3-aminopropyl)-tert-butyloxycarbonylamino]butyl}-tert-butyloxycarbonylamino)propyl]carbamic acid 2-(trimethylsilyl)ethyl ester 
• 71989-38-3 Fmoc-Tyr(tBu)-OH 
• 172992-43-7 pentafluorophenyl butanoate 
• 200125-12-8 N²-(tert-butoxycarbonyl)-N^ω-((2,2,5,7,8-pentamethylchroman-6-yl)sulfonyl)-L-arginine 
• 181524-61-8 O-Benzyl-PhTX-343-N-α-N^G,N^G'-tri-Cbz-L-arginine-amide 
• 130203-14-4 N-Butyryl-O-benzyl-L-tyrosine-spermineamide 

Downstream Products

• 130306-91-1 <127I2>PhTX-343-arginine 

Relevant articles and documents

Solid-phase synthesis of neuroactive spider-wasp hybrid toxin analogues using a backbone amide linker

Polyamine toxins isolated from the venoms of spiders and wasps and their synthetic analogues are uncompetitive antagonists of ligand-gated ionotropic receptors in the central- and peripheral nervous systems, and have proved valuable as tools for the investigation of receptor structure and function. In the present letter we describe the efficient solid-phase synthesis (SPS) of novel hybrid toxins using a BAL resin. This strategy enables the bidirectional construction of toxin molecules and has a potential in SPS of chemically diverse libraries of toxin analogues for structure-activity relationship (SAR) studies.