130234-70-7

Basic information

• Product Name: Benzamide, 2-hydroxy-N-2-thiazolyl-
• CAS NO: 130234-70-7
• Molecular Formula: C10H8N2O2S
• Molecular Weight: 220.252
• Mol File: 130234-70-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Benzamide, 2-hydroxy-N-2-thiazolyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, 2-hydroxy-N-2-thiazolyl-(130234-70-7)
• EPA Substance Registry System: Benzamide, 2-hydroxy-N-2-thiazolyl-(130234-70-7)

Safety Data

• Hazardous Substances Data: 130234-70-7(Hazardous Substances Data)

Upstream product

• 96-50-4 2-thiazolylamine 
• 1441-87-8 salicyloyl chloride 
• 5538-51-2 O-acetylsalicyloyl chloride 
• 55981-09-4 nitazoxanide 
• 57-57-8 β-Propiolactone 
• 79-10-7 acrylic acid 
• 590-92-1 3-Bromopropionic acid 
• 118-55-8 phenyl Salicylate 
• 402848-76-4 2-acetoxybenzoyl-N-(thiazol-2-yl)amide 

Downstream Products

• 1109285-77-9 2-(thiazol-2-ylcarbamoyl)phenyl methanesulfonate 

Relevant articles and documents

Stripping voltammetric methods for determination of the antiparasitic drug nitazoxanide in bulk form, pharmaceutical formulation and human serum

Cyclic voltammograms of nitazoxanide recorded at the hanging mercury drop electrode in the Britton-Robinson universal buffer of pH values 2 to 11 containing 20percent (v/v) ethanol exhibited a single 4-electron irreversible cathodic peak corresponding to the reduction of its NO2 group to the hydroxylamine stage. Nitazoxanide was found to adsorb onto surface of the mercury electrode in a monolayer surface coverage of 3.16×10-10 mol cm-2 in which each adsorbed molecule occupies an area of 0.525 nm2. Based on its adsorption behavior onto the mercury electrode surface, validated linear sweep (LS), differential pulse (DP) and square wave (SW) adsorptive cathodic stripping voltammetric methods were described for determination of bulk nitazoxanide. Limits of detection of 1.5×10 -10, 2.4×10-10 and 3.0×10-11 mol L-1 and limits of quantification of 5.0×10-10, 8.0×10-10 and 1.0×10-10 mol L-1 nitazoxanide in the bulk form were achieved by means of the described LS, DP and SW adsorptive cathodic stripping voltammetric methods, respectively. The described methods were successfully applied for determination of nitazoxanide in its pharmaceutical formulation (Cryptonaz powder) and in spiked human serum without the necessity for sample pretreatment, time consuming extraction steps or formation of colored chromogens prior to the analysis. Besides, nitazoxanide was successfully determined without interference from its acid or base-induced degradation products indicating the stability-indicating power of the described voltammetric methods.

Heterocyclic isosters of antimycobacterial salicylanilides

A series of 64 derivatives of substituted heterocyclic analogues of salicylanilides was synthesized. The compounds were evaluated for in vitro antimycobacterial activity against Mycobacterium tuberculosis, Mycobacterium avium and two strains of Mycobacter