130351-68-7Relevant articles and documents
2′,3′-Cyclopropanated Nucleoside Dimers
Yannopoulos, Constantin G.,Zhou, Wen-Qiang,Nower, Peter,Peoc'h, Didier,Sanghvi, Yogesh S.,Just, George
, p. 378 - 380 (1997)
Syntheses of three novel conformationally rigid dimers containing cyclopropyl -amide and -sulfonamide functionalities are described. Their incorporation into an oligonucleotide sequence resulted in considerable lowering of the Tm's in binding to their complementary RNA sequences.
NUCLEIC ACID-POLYPEPTIDE COMPOSITIONS AND USES THEREOF
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Paragraph 0466, (2019/04/27)
Disclosed herein are compositions and pharmaceutical formulations that comprise a binding moiety conjugated to a modified polynucleic acid molecule and a polymer. Also described herein include methods for treating a cancer which utilize a composition or a pharmaceutical formulation comprising a binding moiety conjugated to a polynucleic acid molecule and a polymer.
Synthesis and cell transfection properties of cationic uracil-morpholino tetramer
Paul, Sibasish,Pattanayak, Sankha,Sinha, Surajit
supporting information, p. 1072 - 1076 (2014/02/14)
Synthesis and cell transfection properties of guanidinium-functionalized uracil morpholino tetramer have been reported for the first time. Due to the basic nature of guanidinium groups they remain protonated under physiological conditions. Such cationic tetramer exhibits efficient cellular uptake properties as visualized by microscopy imaging using fluorescent dye BODIPY. 7′-End of this morpholino tetramer was functionalized with an azide group for conjugation with various types of biomolecules or drugs for cellular delivery.