1303536-70-0Relevant articles and documents
INTERMEDIATES OF SITAGLIPTIN AND PREPARATION PROCESS THEREOF
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, (2013/11/05)
Disclosed are intermediates of Sitagliptin, a preparation process thereof, and a process for synthesizing Sitagliptin using these intermediates. Sitagliptin is synthesized by using chiral amino compounds as a raw material, without having to build a chiral center with a chiral asymmetric catalytic hydrogenation, and high-pressure hydrogenation is avoided.
Simple methodology for the preparation of amino alcohols from amino acid esters using nabh4-methanol in THF
Goncalves,Pinheiro,Da Silva,Da Costa,Kaiser,De Souza
experimental part, p. 1276 - 1281 (2011/05/04)
Amino alcohols constitute a very useful and versatile class of organic compounds, with important applications in synthetic and medicinal chemistry. However, in most of the procedures described in the literature for the obtainment of these compounds, considerable limitations can be found, such as drastic conditions, long time reactions, poor yields, and purification problems. The present article describes a methodology that gives amino alcohols and N-protected amino alcohols based on the reduction of amino acid esters under mild conditions, employing NaBH4 in the presence of methanol. The reactions occurred in a short time (15-20min) and provide yields of 50-95%.
