1304033-80-4

Basic information

• Product Name: 6-benzoyl-5-ethyl-1-((4-fluorophenethoxy)methyl)pyrimidine-2,4(1H,3H)-dione
• Synonyms: 6-benzoyl-5-ethyl-1-((4-fluorophenethoxy)methyl)pyrimidine-2,4(1H,3H)-dione
• CAS NO: 1304033-80-4
• Molecular Weight: 396.418
• Mol File: 1304033-80-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6-benzoyl-5-ethyl-1-((4-fluorophenethoxy)methyl)pyrimidine-2,4(1H,3H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 6-benzoyl-5-ethyl-1-((4-fluorophenethoxy)methyl)pyrimidine-2,4(1H,3H)-dione(1304033-80-4)
• EPA Substance Registry System: 6-benzoyl-5-ethyl-1-((4-fluorophenethoxy)methyl)pyrimidine-2,4(1H,3H)-dione(1304033-80-4)

Safety Data

• Hazardous Substances Data: 1304033-80-4(Hazardous Substances Data)

Upstream product

• 198555-41-8 (5-ethyl-2,6-dimethoxypyrimidin-4-yl)(phenyl)methanone 
• 7589-27-7 2-(4-Fluorophenyl)ethanol 
• 120268-44-2 5-ethyl-6-chloro-2,4-dimethoxypyrimidine 
• 2518-72-1 5-ethyl barbituric acid 
• 1780-38-7 2,4,6-trichloro-5-ethylpyrimidine 
• 182949-79-7 4-fluorophenethyl chloromethyl ether 

Downstream Products

• 1304033-88-2 6-benzoyl-5-ethyl-1-((4-fluorophenethoxy)methyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione 

Relevant articles and documents

6-Benzoyl-3-hydroxypyrimidine-2,4-diones as dual inhibitors of HIV reverse transcriptase and integrase

N-3-Hydroxylation of pyrimidine-2,4-diones was recently found to yield inhibitors of both HIV-1 reverse transcriptase (RT) and integrase (IN). An extended series of analogues featuring a benzoyl group at the C-6 position of the pyrimidine ring was synthesized. Through biochemical studies it was found that these new analogues are dually active against both RT and IN in low micromolar range. Antiviral assays confirmed that these new inhibitors are active against HIV-1 in cell culture at nanomolar to low micromolar range, further validating 3-hydroxypyrimidine-2,4-diones as a viable scaffold for antiviral development.