1306760-86-0 Usage
Description
5-(3-(1S)-1-[(2-hydroxyethyl)amino]-2,3-dihydro-1H-inden-4-yl-1,2,4-oxadiazol-5-yl)-2-[(propan-2-yl)oxy]benzonitrile is a complex organic compound with a unique molecular structure. It is characterized by its 1,2,4-oxadiazol-5-yl and benzonitrile functional groups, which contribute to its potential applications in various fields.
Uses
1. Used in Pharmaceutical Industry:
5-(3-(1S)-1-[(2-hydroxyethyl)amino]-2,3-dihydro-1H-inden-4-yl-1,2,4-oxadiazol-5-yl)-2-[(propan-2-yl)oxy]benzonitrile is used as a modulator for the treatment of multiple sclerosis. Its unique molecular structure allows it to selectively target sphingosine 1-phosphate receptor 1 and 5, playing a crucial role in the regulation of immune responses and reducing inflammation associated with the disease.
2. Used in Antibiotic Applications:
In the field of antibiotics, 5-(3-(1S)-1-[(2-hydroxyethyl)amino]-2,3-dihydro-1H-inden-4-yl-1,2,4-oxadiazol-5-yl)-2-[(propan-2-yl)oxy]benzonitrile demonstrates potential as an antimicrobial agent. Its ability to interfere with bacterial cell processes and inhibit their growth makes it a promising candidate for the development of new antibiotics to combat drug-resistant bacteria.
3. Used in Drug Delivery Systems:
Similar to gallotannin, 5-(3-(1S)-1-[(2-hydroxyethyl)amino]-2,3-dihydro-1H-inden-4-yl-1,2,4-oxadiazol-5-yl)-2-[(propan-2-yl)oxy]benzonitrile can also be employed in drug delivery systems to enhance its bioavailability and therapeutic outcomes. By incorporating this compound into various organic and metallic nanoparticles, its delivery and efficacy against specific targets can be improved, leading to better treatment options for various diseases and conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 1306760-86-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,0,6,7,6 and 0 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1306760-86:
(9*1)+(8*3)+(7*0)+(6*6)+(5*7)+(4*6)+(3*0)+(2*8)+(1*6)=150
150 % 10 = 0
So 1306760-86-0 is a valid CAS Registry Number.
1306760-86-0Relevant articles and documents
Enantioselective Synthesis of Ozanimod, the Active Pharmaceutical Ingredient of a New Drug for Multiple Sclerosis
Cianferotti, Claudio,Barreca, Giuseppe,Bollabathini, Venkatesh,Carcone, Luca,Grainger, Damian,Staniland, Samantha,Taddei, Maurizio
, p. 1924 - 1930 (2021/04/05)
We report here a short enantioselective synthesis of Ozanimod, a potent modulator of the enzyme Sphingosine-1-phosphate receptor (S1PR), recently approved by FDA and EMA for the treatment of relapsing-remitting multiple sclerosis. Amongst different synthetic approaches explored, we achieved the best result introducing the stereogenic centre in the last step through imine asymmetric transfer hydrogenation (ATH) using Wills’ catalysts. Besides the reduced numbers of enantiomeric purity controls required, this process culminates in an exceptionally high enantioselective reductive amination obtained with commercially available tethered Ru catalysts. Starting from commercially available 4-cyano-indanone, enantiomerically pure Ozanimod was obtained in 5 steps in 62 % overall yield and 99 % ee.
PROCESS FOR THE PREPARATION OF SPHINGOSINE-1-PHOSPHATE RECEPTOR AGONIST
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, (2020/05/13)
Industrially viable and advantageous processes for the preparation of Ozanimod are described. The invention also discloses the intermediates obtained in the process.
A PROCESS FOR THE PREPARATION OF OZANIMOD AND ITS INTERMEDIATE (S)-1-AMINO-2,3-DIHYDRO-1H-INDENE-4-CARBONITRILE
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Page/Page column 18-20, (2020/05/07)
The present invention relates to an improved process for preparation of Ozanimod (I) or pharmaceutically acceptable salts thereof. The present invention also relates to an improved process for preparation of (S)-l-amino-2,3-dihydro- 1H-indene-4-carbonitrile (II) or its optically active acid salts.
