130743-07-6 Usage
Description
Quinaldopeptin is a quinomycin antibiotic, a symmetrical, cyclic decapeptide derived from an Amycolatopsis sp. It is characterized by its bis-intercalating activity with DNA, which contributes to its potent in vitro antimicrobial and cytotoxic properties. Quinaldopeptin is related to luzopeptins and sandramycin, and it has demonstrated significant benefits in prolonging the survival time of mice inoculated with a murine tumor and exhibiting weak nematocidal activity.
Uses
Used in Pharmaceutical Industry:
Quinaldopeptin is used as an antimicrobial agent for its strong in vitro activity against a variety of bacteria, including S. pyogenes, S. aureus, C. perfringens, S. faecalis, E. coli, and K. pneumoniae. Its potent action against these bacteria makes it a valuable candidate for the development of new antibiotics to combat drug-resistant infections.
Used in Oncology:
Quinaldopeptin is used as an anticancer agent due to its cytotoxic effects on B16/F10 and Moser cells, with low IC50 values of 0.0008 and 0.04 μg/ml, respectively. It also increases survival in a P388 leukemia mouse model, indicating its potential in the treatment of various types of cancer.
Used in Antimicrobial Research:
As a bis-intercalating cyclic peptide antibiotic, quinaldopeptin is used in research to better understand the mechanisms of action of DNA-intercalating agents and their potential applications in the development of novel antimicrobial drugs.
Used in Drug Design:
Quinaldopeptin's unique structure and bis-intercalating properties make it a valuable compound for drug design, particularly in the development of new antibiotics and anticancer agents that target DNA. Its interaction with DNA (Kd = 32 nM) provides insights into the design of more effective and selective drugs.
Check Digit Verification of cas no
The CAS Registry Mumber 130743-07-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,0,7,4 and 3 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 130743-07:
(8*1)+(7*3)+(6*0)+(5*7)+(4*4)+(3*3)+(2*0)+(1*7)=96
96 % 10 = 6
So 130743-07-6 is a valid CAS Registry Number.
InChI:InChI=1/C62H78N14O14/c1-35-51(69-59(87)53-45(77)29-37-17-5-7-19-39(37)67-53)61(89)75-27-15-11-21-41(75)55(83)63-31-47(79)72(4)34-50(82)74-26-14-10-24-44(74)58(86)66-36(2)52(70-60(88)54-46(78)30-38-18-6-8-20-40(38)68-54)62(90)76-28-16-12-22-42(76)56(84)64-32-48(80)71(3)33-49(81)73-25-13-9-23-43(73)57(85)65-35/h5-8,17-20,29-30,35-36,41-44,51-52,77-78H,9-16,21-28,31-34H2,1-4H3,(H,63,83)(H,64,84)(H,65,85)(H,66,86)(H,69,87)(H,70,88)
