130756-35-3Relevant articles and documents
STRUCTURE OF CLOVANEMAGNOLOL, A NOVEL NEUROTROPHIC SESQUITERPENE-NEOLIGNAN FROM MAGNOLIA OBOVATA
Fukuyama, Yoshiyasu,Otoshi, Yukio,Kodama, Mitsuaki
, p. 4477 - 4480 (1990)
The structure of novel sesquiterpene-neolignan, clovanemagnolol (1), isolated from the bark of Magnolia Obovata has been elucidated on the basis of the extensive 2D-NMR analyses and finally substantiated by one-step biomimetic synthesis from caryphyllene
Hippocampal and cortical neuronal growth mediated by the small molecule natural product clovanemagnolol
Khaing, Zin,Kang, Danby,Camelio, Andrew M.,Schmidt, Christine E.,Siegel, Dionicio
, p. 4808 - 4812 (2011/09/21)
The use of small molecule surrogates of growth factors that directly or indirectly promote growth represents an attractive approach to regenerative medicine. With synthetic access to clovanemagnolol, a small molecule initially isolated from the bark of th
NEUROTROPHIC SESQUITERPENE-NEOLIGNANS FROM MAGNOLIA OBOVATA: STRUCTURE AND NEUROTROPHIC ACTIVITY
Fukuyama, Yoshiyasu,Otoshi, Yukio,Miyoshi, Kumi,Nakamura, Kazuhiko,Kodama, Mitsuaki,et al.
, p. 377 - 392 (2007/10/02)
Novel sesquiterpene-neolignans, eudesobovatols A (1) and B (2), eudesmagnolol (3), eudeshonokiols A (4) and B (5), clovanemagnolol (6), and caryolanemagnolol (7), have been isolated from the bark of Magnolia obovata.Their structures were elucidated to be sesquiterpenes (eudesmol, 4,4,8-trimethyltricyclo2,5>dodecane-1,9-diol, and clovanediol) combined through ether bond with neolignans such as obovatol, honokiol, and magnolol on the basis of spectral data, degradation, and/or synthesis.Compounds 1, 6, and 7 were found to exhibit interesting neurotrophic activity on a neuronal cell culture system derived from fetal rat hemisphere.