130796-32-6

Basic information

• Product Name: (4S,5R)-trans-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-carbaldehyde
• Synonyms: (4S,5R)-trans-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-carbaldehyde
• CAS NO: 130796-32-6
• Molecular Weight: 206.241
• Mol File: 130796-32-6.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: (4S,5R)-trans-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-carbaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: (4S,5R)-trans-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-carbaldehyde(130796-32-6)
• EPA Substance Registry System: (4S,5R)-trans-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-carbaldehyde(130796-32-6)

Safety Data

• Hazardous Substances Data: 130796-32-6(Hazardous Substances Data)

Upstream product

• 343953-79-7 2,2-Dimethyl-5-phenyl-[1,3]dioxolane-4-carbonitrile 
• 130718-66-0 (R)-3-phenyl-1,1-bis(p-tolylthio)-3-(trimethylsilyloxy)propan-2-one 
• 130718-75-1 (4R,5R)-cis-4--2,2-dimethyl-5-phenyl-1,3-dioxolan 
• 130718-68-2 (R)-3-hydroxy-3-phenyl-1,1-bis(p-tolylthio)propan-2-one 
• 130718-73-9 threo (2S,3R)-3-phenyl-1,1-bis(p-tolylthio)propane-2,3-diol 
• 130718-71-7 erythro (2R,3R)-3-phenyl-1,1-bis(p-tolylthio)propane-2,3-diol 
• 109459-35-0 methyl (R)-2-phenyl-2-((trimethylsilyl)oxy)acetate 
• 214194-15-7 (4S,5R)-2,2-dimethyl-5-phenyl-[1,3]dioxolane-4-carboxylic acid methyl ester 
• 103-26-4 Methyl cinnamate 
• 124649-67-8 methyl (2S,3R)-3-phenyl-2,3-dihydroxypropanoate 
• 133520-57-7 (4S,5R)-4-(hydroxymethyl)-2,2-dimethyl-5-phenyl-1,3-dioxolane 
• 133521-66-1 (4S,5R)-Ethyl 2,2-dimethyl-5-phenyl-1,3-dioxolane-4-carboxylate 
• 130796-29-1 (4S,5R)-trans-4--2,2-dimethyl-5-phenyl-1,3-dioxolan 
• 130718-77-3 (4R,5R)-cis-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-carbaldehyde 

Downstream Products

• 133421-03-1 [1-((4R,5R)-2,2-Dimethyl-5-phenyl-[1,3]dioxolan-4-yl)-meth-(Z)-ylidene]-((R)-2-methoxymethyl-pyrrolidin-1-yl)-amine 
• 130796-35-9 (4S,5R)-trans-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-carboxylic acid 
• 910484-74-1 (S)-1-{(4R,5R)-2,2-dimethyl-5-phenyl[1,3]dioxolan-4-yl}-2,2-difluorobut-3-en-1-ol 
• 910484-75-2 (R)-1-{(4R,5R)-2,2-dimethyl-5-phenyl[1,3]dioxolan-4-yl}-2,2-difluorobut-3-en-1-ol 
• 910484-78-5 acrylic acid (R)-1-{(4R,5R)-2,2-dimethyl-5-phenyl[1,3]dioxolan-4-yl}-2,2-difluorobut-3-enyl ester 
• 910484-79-6 (S)-6-{(4S,5R)-2,2-dimethyl-5-phenyl[1,3]dioxolan-4-yl}-5,5-difluoro-5,6-dihydropyran-2-one 
• 910484-80-9 (R)-6-{(4S,5R)-2,2-dimethyl-5-phenyl[1,3]dioxolan-4-yl}-5,5-difluoro-5,6-dihydropyran-2-one 
• 910484-77-4 acrylic acid (S)-1-{(4R,5R)-2,2-dimethyl-5-phenyl[1,3]dioxolan-4-yl}-2,2-difluorobut-3-enyl ester 
• 124649-67-8 methyl (2S,3R)-3-phenyl-2,3-dihydroxypropanoate 
• 1422559-83-8 (S)-((4S,5R)-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-yl)((R)-5-oxo-2,5-dihydrofuran-2-yl)methyl acetate 
• 1422559-84-9 (S)-((4S,5R)-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-yl)((S)-5-oxo-2,5-dihydrofuran-2-yl)methyl acetate 
• 1422559-73-6 (E)-5-(((4R,5R)-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-yl)methylene)furan-2(5H)-one 
• 918906-87-3 8-epi-crassalactone D 
• 1422559-76-9 (5R,7R,8S,9S)-9-bromo-8-hydroxy-7-phenyl-1,6-dioxaspiro[4.4]non-3-en-2-one 

Relevant articles and documents

Asymmetric Total Syntheses of Aetheramides and Their Stereoisomers: Stereochemical Assignment of Aetheramides

The concise total syntheses of the potent HIV inhibitors aetheramides A and B (IC50 values of 15 and 18 nM), as well as three pairs of their stereoisomers, were achieved, which allowed the complete stereochemical assignment of aetheramides for the first time. With a longest linear sequence of 15 steps, the convergent, fully stereocontrolled route provided aetheramides A and B in 5.3% and 3.6% yields, respectively. The synthetic strategy features efficient Stille coupling for macrocyclization, asymmetric aldol reactions to establish the ambiguous stereochemistries at C-17 and C-26, and implementation of mild conditions to avoid the epimerization of the sensitive polyketide moiety and the migration of the labile lactone.

Oxidative cyclization of γ-alkylidene butenolides. Stereoselective preparation of spirolactones

A new route to 1,6-dioxaspiro[4.4]non-3-en-2-ones is established by bromoetherification of dihydroxybutenolides. An asymmetric total synthesis of 8-epi-crassalactone D starting from methyl cinnamate has been accomplished. ARKAT-USA, Inc.

Stereocontrolled synthesis of gem-difluoromethylenated goniodiols and goniothalamin epoxides based on ring-closing metathesis

An efficient and general method to stereoselectively synthesize gem-difluoromethylenated goniodiols and goniothalamin epoxides has been developed. The introduction of a gem-difluoromethyl-containing group was achieved by the reaction of aldehydes with 3-bromo-3,3-difluoropropene in the presence of indium. The gem-difluoromethylenated α,β-unsaturated- δ-lactone moiety was constructed through the ring-closing metathesis of highly electron-deficient gew-difluoromethylenated acryloyl esters by Grubbs' II catalyst in toluene at reflux. Georg Thieme Verlag Stuttgart.