1309446-13-6 Usage
Description
(Ra)-3,3’-bis(2,4,6-tricyclohexylphenyl)-[1,1’-binaphthalene]-2,2’-diol is a diol compound that features two phenyl groups and two naphthalene moieties. It is a chiral molecule, with its stereochemistry designated as "R." (Ra)-3,3’-bis(2,4,6-tricyclohexylphenyl)-[1,1’-binaphthalene]-2,2’-diol is known for its unique structure, which includes tricyclohexylphenyl groups that provide steric hindrance, making it an effective chiral ligand for various applications.
Uses
Used in Asymmetric Synthesis:
(Ra)-3,3’-bis(2,4,6-tricyclohexylphenyl)-[1,1’-binaphthalene]-2,2’-diol is used as a chiral ligand in asymmetric synthesis for promoting various transition metal-catalyzed reactions. Its steric hindrance and chiral structure make it a valuable component in the synthesis of enantiomerically pure compounds, which are essential in the pharmaceutical industry and other fields.
Used in Analytical Chemistry:
In the field of analytical chemistry, (Ra)-3,3’-bis(2,4,6-tricyclohexylphenyl)-[1,1’-binaphthalene]-2,2’-diol is used in the preparation of chiral stationary phases for high-performance liquid chromatography (HPLC). Its chiral properties allow for the separation and analysis of enantiomers, which is crucial in understanding the different biological activities and properties of chiral compounds.
Used in Pharmaceutical Industry:
(Ra)-3,3’-bis(2,4,6-tricyclohexylphenyl)-[1,1’-binaphthalene]-2,2’-diol is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its chiral nature and ability to act as a chiral ligand make it an essential component in the development of enantiomerically pure drugs, which can have significant implications for the efficacy and safety of medications.
Used in Chemical Research:
In the field of chemical research, (Ra)-3,3’-bis(2,4,6-tricyclohexylphenyl)-[1,1’-binaphthalene]-2,2’-diol is used as a model compound for studying the effects of steric hindrance and chirality on chemical reactions and processes. This helps researchers to better understand the underlying principles of asymmetric synthesis and develop new strategies for the production of enantiomerically pure compounds.
Overall, (Ra)-3,3’-bis(2,4,6-tricyclohexylphenyl)-[1,1’-binaphthalene]-2,2’-diol is a versatile and valuable compound in the fields of organic synthesis, analytical chemistry, pharmaceuticals, and chemical research due to its unique chiral structure and properties as a chiral ligand.
Check Digit Verification of cas no
The CAS Registry Mumber 1309446-13-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,0,9,4,4 and 6 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1309446-13:
(9*1)+(8*3)+(7*0)+(6*9)+(5*4)+(4*4)+(3*6)+(2*1)+(1*3)=146
146 % 10 = 6
So 1309446-13-6 is a valid CAS Registry Number.
1309446-13-6Relevant articles and documents
An Alternative Synthesis of Cycloalkyl-Substituted CPA Catalysts and Application in Asymmetric Protonation Reactions**
McLean, Liam A.,Watson, Allan J. B.
, p. 4943 - 4945 (2021/09/28)
An alternative synthesis of cycloalkyl-substituted CPA catalysts is reported. A Negishi coupling offers improved yields and purity of the necessary 1,3,5-tri(cycloalkyl)benzenes. Limitations in the use of commercial organozinc reagents have been identifie
Enantioselective organocatalytic fluorination-induced Wagner-Meerwein rearrangement
Romanov-Michailidis, Fedor,Guénée, Laure,Alexakis, Alexandre
supporting information, p. 9266 - 9270 (2013/09/12)
Cracked under strain: Strained allylic cyclobutanols and cyclopropanols readily undergo a ring expansion described by the title rearrangement. This reaction is promoted by catalytic amounts of 1 and displays high tolerance with respect to the substrate scope. The corresponding β-fluoro spiroketone products are isolated in high yields and with excellent stereoselectivities. EDG=electron-donating group, EWG=electron-withdrawing group. Copyright
