1309456-83-4

Basic information

• Product Name: (R)-5-(4-fluorophenyl)-2-methyl-3,4-dihydro-2H-pyrrole
• Synonyms: (R)-5-(4-fluorophenyl)-2-methyl-3,4-dihydro-2H-pyrrole
• CAS NO: 1309456-83-4
• Molecular Weight: 177.221
• Mol File: 1309456-83-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (R)-5-(4-fluorophenyl)-2-methyl-3,4-dihydro-2H-pyrrole(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-5-(4-fluorophenyl)-2-methyl-3,4-dihydro-2H-pyrrole(1309456-83-4)
• EPA Substance Registry System: (R)-5-(4-fluorophenyl)-2-methyl-3,4-dihydro-2H-pyrrole(1309456-83-4)

Safety Data

• Hazardous Substances Data: 1309456-83-4(Hazardous Substances Data)

Upstream product

• 259857-49-3 tert-butyl (3R)-3-methyl-2-oxopyrrolidine-1-carboxylate 
• 352-34-1 4-fluoro-1-iodobenzene 
• 123183-95-9 1-(4-fluoro-phenyl)-pentane-1,4-dione 
• 403-43-0 4-fluorobenzoyl chloride 
• 119830-49-8 2-(4-fluorophenyl)-5-methyl-1H-pyrrole 

Relevant articles and documents

A class of histone acetylase p300 inhibitors, and application thereof

The invention discloses a class of histone acetylase p300 inhibitors, and application thereof, and belongs to the technical field of medicinal chemistry. The invention discloses a compound representedby a formula (I), or a stereochemical isomer, a solvate or a pharmaceutically acceptable salt thereof. According to the invention, the compound can effectively inhibit the activity of histone acetylase p300 and can effectively inhibit the proliferation activity of various tumor cells; the compound is combined with a CDK4/6 inhibitor to play a synergistic role in inhibiting proliferation of tumorcells; and the compound has good application prospects in preparation of histone acetylase inhibitors, preparation of drugs for preventing and/or treating cancers, metabolic diseases, neurological diseases or inflammations, and combination of drugs.

Highly enantioselective partial hydrogenation of simple pyrroles: A facile access to chiral 1-pyrrolines

A highly enantioselective Pd-catalyzed partial hydrogenation of simple 2,5-disubstituted pyrroles with a Bronsted acid as an activator has been successfully developed, providing chiral 2,5-disubstituted 1-pyrrolines with up to 92% ee.