1309571-54-7Relevant articles and documents
Anticancer properties of an important drug lead podophyllotoxin can be efficiently mimicked by diverse heterocyclic scaffolds accessible via one-step synthesis
Magedov, Igor V.,Frolova, Liliya,Manpadi, Madhuri,Bhoga, Uma Devi,Tang, Hong,Evdokimov, Nikolai M.,George, Olivia,Hadje Georgiou, Kathy,Renner, Steffen,Getlik, Matth?us,Kinnibrugh, Tiffany L.,Fernandes, Manuel A.,Van Slambrouck, Severine,Steelant, Wim F. A.,Shuster, Charles B.,Rogelj, Snezna,Van Otterlo, Willem A. L.,Kornienko, Alexander
, p. 4234 - 4246 (2011)
Structural simplification of an antimitotic natural product podophyllotoxin with mimetic heterocyclic scaffolds constructed using multicomponent reactions led to the identification of compounds exhibiting low nanomolar antiproliferative and apoptosis-indu