130979-57-6

Basic information

• Product Name: (+/-)-trans-(2R,3S)-7-chloro-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4-[5H]-one
• CAS NO: 130979-57-6
• Molecular Weight: 335.811
• Mol File: 130979-57-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (+/-)-trans-(2R,3S)-7-chloro-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4-[5H]-one(CAS DataBase Reference)
• NIST Chemistry Reference: (+/-)-trans-(2R,3S)-7-chloro-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4-[5H]-one(130979-57-6)
• EPA Substance Registry System: (+/-)-trans-(2R,3S)-7-chloro-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4-[5H]-one(130979-57-6)

Safety Data

• Hazardous Substances Data: 130979-57-6(Hazardous Substances Data)

Upstream product

• 105560-93-8 methyl (2R,3S)-3-(4-methoxyphenyl)glycidate 
• 1004-00-8 4-chloro-2-aminobenzenethiol 
• 30067-00-6 methyl 2-hydroxy-3-(4-methoxyphenyl)-3-(2-nitrophenylthio)propionate 
• 30067-06-2 2-Hydroxy-3-(4-methoxy-phenyl)-3-(2-nitro-phenylsulfanyl)-propionic acid 

Relevant articles and documents

Facile ionic liquid-mediated protocol for the regioselective synthesis of 1,5-benzothiazepines

An efficient one-step ionic liquid-mediated green protocol for the regioselective synthesis of (+)=(±)-cis-2-(4-methoxy/benzyloxyphenyl)-3- hydroxy-2,3-dihydro-1,5- benzothiazepin-4-[5H]-ones has been developed from the reaction between substituted 2-aminobenzenethiol and methyl-(±)-trans-3- (4-methoxy/benzyloxy phenyl)glycidate, under nitrogen atmosphere, at 60±2 °C. The reaction has been performed in ionic liquids (viz, 1-butyl-3-methylimidazolium bromide/hexafluorophosphate), and the yields of the 1,5-benzothiazepine derivatives were found to be excellent. The cis-stereoisomer was obtained as the major product along with a trans-isomer as minor product.