13129-58-3

Basic information

• Product Name: 6-Methoxyphenazin-1-ol
• Synonyms: 1-Hydroxy-6-methoxyphenazine;6-Methoxyphenazin-1-ol
• CAS NO: 13129-58-3
• Molecular Formula: C₁₃H₁₀N₂O₂
• Molecular Weight: 0
• Mol File: 13129-58-3.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6-Methoxyphenazin-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Methoxyphenazin-1-ol(13129-58-3)
• EPA Substance Registry System: 6-Methoxyphenazin-1-ol(13129-58-3)

Safety Data

• Hazardous Substances Data: 13129-58-3(Hazardous Substances Data)

Usage

General Description

6-Methoxyphenazin-1-ol, also known as 6-methoxy-phenazin-1-ol, is a chemical compound with the molecular formula C12H9NO2. It is a phenazine derivative with a methoxy group attached to the 6-position of the phenazine ring and a hydroxyl group at the 1-position. 6-Methoxyphenazin-1-ol has been studied for its potential pharmaceutical and biomedical applications, including its antibacterial and antitumor properties. It has also been investigated for its potential use in organic electronics and as a colorimetric sensor for various analytes. Its unique structural features and promising potential make 6-methoxyphenazin-1-ol an interesting compound for further research and development.

Upstream product

• 23462-25-1 phenazine-1,6-dicarboxylic acid 
• 69-48-7 phenazine-1,6-diol 
• 485-80-3 S-adenosyl-L-methionine 
• 112970-44-2 2-bromo-3-methoxyaniline 
• 74-88-4 methyl iodide 
• 90-04-0 2-methoxy-phenylamine 
• 13398-79-3 1,6-dimethoxyphenazine 
• 91-23-6 2-Nitroanisole 

Downstream Products

• 13129-57-2 1-hydroxy-6-methoxyphenazine N₁₀-oxide 
• 13925-12-7 1-hydroxy-6-methoxy-phenazine-N₅,N₁₀-dioxide 
• 1350729-67-7 1-(t-butyldiphenylsilyloxy)-6-methoxyphenazine 

Relevant articles and documents

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Total synthesis and antileukemic evaluations of the phenazine 5,10-dioxide natural products iodinin, myxin and their derivatives

A new efficient total synthesis of the phenazine 5,10-dioxide natural products iodinin and myxin and new compounds derived from them was achieved in few steps, a key-step being 1,6-dihydroxyphenazine di-N-oxidation. Analogues prepared from iodinin, including myxin and 2-ethoxy-2-oxoethoxy derivatives, had fully retained cytotoxic effect against human cancer cells (MOLM-13 leukemia) at atmospheric and low oxygen level. Moreover, iodinin was for the first time shown to be hypoxia selective. The structure-activity relationship for leukemia cell death induction revealed that the level of N-oxide functionality was essential for cytotoxicity. It also revealed that only one of the two phenolic functions is required for activity, allowing the other one to be modified without loss of potency.