1313363-54-0 Usage
General Description
NVP-CGM097 is a potent and selective small molecule inhibitor of the protein kinase A, known as p70S6K, which regulates cell growth, survival, and proliferation. It functions by directly binding to and inhibiting the activity of p70S6K, thereby reducing the phosphorylation of its downstream targets. This inhibition leads to the suppression of cell cycle progression and the induction of cell death in various cancer cell lines. NVP-CGM097 has shown promising results in preclinical studies, with the potential to be developed as a targeted therapy for cancers driven by hyperactive p70S6K signaling. It has also demonstrated good oral bioavailability and tolerability in animal models, making it a strong candidate for further development as an anticancer agent.
Check Digit Verification of cas no
The CAS Registry Mumber 1313363-54-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,1,3,3,6 and 3 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1313363-54:
(9*1)+(8*3)+(7*1)+(6*3)+(5*3)+(4*6)+(3*3)+(2*5)+(1*4)=120
120 % 10 = 0
So 1313363-54-0 is a valid CAS Registry Number.
1313363-54-0Relevant articles and documents
A p53 - MDM2 binding inhibitor dihydroxy isoquinoline derivative synthesis method
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, (2017/07/06)
The invention discloses a synthetic method for preparing a non-peptide p53-MDM2-binding inhibitor dyhydroxyl quinoline derivative. The method comprises the following steps of: carrying out reductive amination on a compound 1 and a compound 2 to obtain a compound 3; and carrying out substitution, oxidization, reductive amination and deprotection amidation reaction to prepare a compound I. The synthetic method adopts a brand-new synthesis route, is simple and convenient to operate, high in yield, good in safety, environmentally-friendly, low in cost, and beneficial for technical production. FORMULA as shown in the specification.
CRYSTALLINE FORM OF AN INHIBITOR OF MDM2/4 AND P53 INTERACTION
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, (2013/09/26)
A crystalline form of (S)-1-(4-Chloro-phenyl)-7-isopropoxy-6-methoxy-2-(4-{methyl-[4-(4-methyl-3-oxo-piperazin-1-yl)-trans-cyclohexylmethyl]-amino}-phenyl)-1,4-dihydro-2H-isoquinolin-3-one, which is useful in the treatment of a disease or disorder associated with the interaction between p53, or variants thereof, and MDM2 and/or MDM4, or variants thereof, respectively.