13140-69-7

Basic information

• Product Name: Thiourea, N-phenyl-N'-3-pyridinyl-
• CAS NO: 13140-69-7
• Molecular Formula: C12H11N3S
• Molecular Weight: 229.305
• Mol File: 13140-69-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Thiourea, N-phenyl-N'-3-pyridinyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Thiourea, N-phenyl-N'-3-pyridinyl-(13140-69-7)
• EPA Substance Registry System: Thiourea, N-phenyl-N'-3-pyridinyl-(13140-69-7)

Safety Data

• Hazardous Substances Data: 13140-69-7(Hazardous Substances Data)

Upstream product

• 462-08-8 pyridin-3-ylamine 
• 103-72-0 phenyl isothiocyanate 

Downstream Products

• 30162-37-9 3-pyridylthiourea 
• 709000-28-2 [4-(3,4-dimethoxyphenyl)-thiazol-2-yl]-pyridin-3-yl-amine 
• 781566-78-7 N-phenyl-N'-(3-pyridyl)-1-pyrrolidinocarboxamidine 
• 69437-86-1 2-phenylimino-3-pyridin-3-yl-thiazolidin-4-one 
• 1205532-79-1 CuI(N-(3-pyridyl)-N'-phenylthiourea) 
• 854392-31-7 2-methyl-1-phenyl-3-pyridin-3-yl-isothiourea 

Relevant articles and documents

Hydrogen-bonding networks in heterocyclic thioureas

The synthesis of heterocyclic thioureas from heterocyclic amines with phenyl- or methylisothiocyanate or CS2 is described. Seven new X-ray crystal structures are reported: In N-(3-pyridyl)-N'-phenylthiourea (Pna2 1, a = 10.1453(3), b

2-aminothiazoles as therapeutic leads for prion diseases

2-Aminothiazoles are a new class of small molecules with antiprion activity in prion-infected neuroblastoma cell lines (J. Virol. 2010, 84, 3408). We report here structure-activity studies undertaken to improve the potency and physiochemical properties of 2-aminothiazoles, with a particular emphasis on achieving and sustaining high drug concentrations in the brain. The results of this effort include the generation of informative structure-activity relationships (SAR) and the identification of lead compounds that are orally absorbed and achieve high brain concentrations in animals. The new aminothiazole analogue (5-methylpyridin-2-yl)-[4-(3-phenylisoxazol-5-yl)-thiazol-2-yl]-amine (27), for example, exhibited an EC50 of 0.94 μM in prion-infected neuroblastoma cells (ScN2a-cl3) and reached a concentration of ～25 μM in the brains of mice following three days of oral administration in a rodent liquid diet. The studies described herein suggest 2-aminothiazoles as promising new leads in the search for effective therapeutics for prion diseases.