13148-81-7

Basic information

• Product Name: 1H-1,2,3-Triazole, 4-(4-chlorophenyl)-1-phenyl-
• CAS NO: 13148-81-7
• Molecular Formula: C14H10ClN3
• Molecular Weight: 255.707
• Mol File: 13148-81-7.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 1H-1,2,3-Triazole, 4-(4-chlorophenyl)-1-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-1,2,3-Triazole, 4-(4-chlorophenyl)-1-phenyl-(13148-81-7)
• EPA Substance Registry System: 1H-1,2,3-Triazole, 4-(4-chlorophenyl)-1-phenyl-(13148-81-7)

Safety Data

• Hazardous Substances Data: 13148-81-7(Hazardous Substances Data)

Upstream product

• 873-73-4 4-n-chlorophenylacetylene 
• 62-53-3 aniline 
• 4251-65-4 (4-chlorophenyl)acetaldehyde 
• 622-37-7 Phenyl azide 
• 99-91-2 para-chloroacetophenone 
• 75230-50-1 p-chloroacetophenone tosylhydrazone 
• 538-51-2 benzylidene phenylamine 
• 128256-29-1 C₁₄H₁₂BrClN₂O₂S 

Relevant articles and documents

Iodine-mediated C-N and N-N bond formation: A facile one-pot synthetic approach to 1,2,3-triazoles under metal-free and azide-free conditions

A novel strategy towards the synthesis of 1,4-disubstituted 1,2,3-triazoles via C-N and N-N bond formation has been demonstrated under transition metal-free and azide-free conditions. These 1,2,3-triazoles were obtained in a regioselective manner from commercially available anilines, aryl alkenes/aryl alkynes and N-tosylhydrazines using I2 under O2 atmosphere. Broad substrate scope, milder reaction conditions, good to moderate yields and clean protocol are the notable features of the method. Moreover, this protocol is amenable for the generation of a library of medicinally important key building blocks.

A supercritical carbon dioxide in the synthesis of 1, 2, 3 - triazole class is the compound of the method

The invention discloses a method for synthesizing a 1,2,3-triazole compound in supercritical carbon dioxide and belongs to the technical field of synthesis of 1,2,3-triazole compounds. The key point of the technical scheme of the invention is as follows:

Novel 1,4-substituted-1,2,3-triazoles as antitubercular agents

Tuberculosis (TB) remains a pressing unmet medical need, particularly with the emergence of multidrug-resistant and extensively drug-resistant tuberculosis. Here, a series of 1,4-substituted-1,2,3-triazoles have been synthesized and evaluated as potential antitubercular agents. These compounds were assembled via click chemistry in high crude purity and in moderate to high yield. Of the compounds tested, 12 compounds showed promising antitubercular activity with six possessing minimum inhibitory concentration (MIC) values -1, and total selectivity for Mycobacterium tuberculosis (Mtb) growth inhibition. A second set of 21 compounds bearing variations on ring C were synthesized and evaluated. This second library gave an additional six compounds displaying MIC values ≤10 μg mL-1 and total selectivity for Mtb growth inhibition. These compounds serve as an excellent starting point for further development of antitubercular therapies.