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131512-90-8

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131512-90-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 131512-90-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,1,5,1 and 2 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 131512-90:
(8*1)+(7*3)+(6*1)+(5*5)+(4*1)+(3*2)+(2*9)+(1*0)=88
88 % 10 = 8
So 131512-90-8 is a valid CAS Registry Number.

131512-90-8Downstream Products

131512-90-8Relevant articles and documents

Discovery of new benzhydrol biscarbonate esters as potent and selective apoptosis inducers of human melanomas bearing the activated ERK pathway: SAR studies on an ERK MAPK signaling modulator, ACA-28

Satoh, Ryosuke,Hamada, Naoya,Yamada, Ami,Kanda, Yuki,Ishikawa, Fumihiro,Takasaki, Teruaki,Tanabe, Genzoh,Sugiura, Reiko

, (2020)

The recent discovery that an ERK signaling modulator [ACA-28 (2a)] preferentially kills human melanoma cell lines by inducing ERK-dependent apoptosis has generated significant interest in the field of anti-cancer therapy. In the first SAR study on 2a, here, we successfully developed candidates (2b, 2c) both of which induce more potent and selective apoptosis towards ERK-active melanoma cells than 2a, thus revealing the structural basis for inducing the ERK-dependent apoptosis and proposing the therapeutic prospect of these candidates against ERK-dependent cancers represented by melanoma.

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