131602-94-3

Basic information

• Product Name: 2-(3-Trifluoromethyl-phenyl)-4H-benzo[1,4]thiazin-3-one
• Synonyms: 2-(3-Trifluoromethyl-phenyl)-4H-benzo[1,4]thiazin-3-one
• CAS NO: 131602-94-3
• Molecular Weight: 309.312
• Mol File: 131602-94-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(3-Trifluoromethyl-phenyl)-4H-benzo[1,4]thiazin-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-Trifluoromethyl-phenyl)-4H-benzo[1,4]thiazin-3-one(131602-94-3)
• EPA Substance Registry System: 2-(3-Trifluoromethyl-phenyl)-4H-benzo[1,4]thiazin-3-one(131602-94-3)

Safety Data

• Hazardous Substances Data: 131602-94-3(Hazardous Substances Data)

Upstream product

• 62451-84-7 (3-trifluoromethyl-phenyl)-acetic acid methyl ester 
• 1141-88-4 2-Aminophenyl disulfide 
• 5325-20-2 2H-1,4-benzothiazin-3-one 
• 98-15-7 3-chlorotrifluoromethylbenzene 

Relevant articles and documents

Expeditious synthesis of C2- or N4-aryl-1,4-benzothiazin-3-one via orthogonal Pd-catalyzed C-arylation and Cu-catalyzed N-arylation

Direct, chemo-specific arylation at C-2 or N-4 of 1,4-benzothiazin-3-one with aryl halides, based on Pd or Cu catalyst system, respectively, provided easy entry to arylated derivatives, a class of molecules not easily accessible via existing methods. Under Pd-catalysis conditions with LiHMDS as the base, N-arylation of 1,4-benzothiazin-3-one was inhibited leading to Cα-arylation of a secondary amide without the need for protection and de-protection of more acidic amido NH.