13171-18-1Relevant articles and documents
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Speers,L. et al.
, p. 593 - 595 (1971)
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Sensory irritation mechanisms investigated from model compounds: Trifluoroethanol, hexafluoroisopropanol and methyl hexafluoroisopropyl ether
Nielsen, Gunnar D.,Abraham, Michael H.,Hansen, Lea F.,Hammer, Maria,Cooksey, Christopher J.,Andonian-Haftvan, Jenik,Alarie, Yves
, p. 319 - 328 (1996)
Quantitative structure-activity relationships (QSAR) have suggested the importance of hydrogen bonding in relation to activation of the sensory irritant receptor by nonreactive volatile organic chemicals. To investigate this possibility further, three model compounds with different hydrogen bond acidity, trifluoroethanol, hexafluoroisopropanol and methyl hexafluoroisopropyl ether, were selected for study. The potency of each chemical is obtained from the concentration necessary to reduce respiratory rate in mice by 50% (RD50). The RD50 values obtained were: methyl hexafluoroisopropyl ether (≥ 160,000 ppm), trifluoroethanol (11,400-23,300 ppm), and hexafluoroisopropanol (165 ppm). QSAR showed that trifluoroethanol and methyl hexafluoroisopropyl ether behaved as predicted as nonreactive sensory irritants, whereas hexafluoroisopropanol was much more potent than predicted. The higher than predicted potency of hexafluoroisopropanol could be due to a coupled reaction, involving both strong hydrogen bonding and weak Bronsted acidity. A concerted reaction could thus be more efficient in activation of the receptor. Hydrogen bonding properties and concerted reactions may be important in the activation of the sensory irritant receptor by nonreactive volatile organic chemicals.
METHOD FOR PRODUCING FLUORINE-CONTAINING ETHER
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Paragraph 0039-0047, (2020/09/02)
PROBLEM TO BE SOLVED: To provide a method for producing a fluorine-containing ether compound in a safe and efficient manner, in a method for producing a fluorine-containing ether compound using a dialkyl sulfate. SOLUTION: There is provided a method for producing a fluorine-containing ether compound comprising the steps of: (a) reacting a sulfate-forming agent with a first alcohol compound at 50 to 200°C under reduced pressure in a first reactor to generate a gas containing a dialkyl sulfate; and (b) reacting an aqueous solution containing a metal fluorine-containing alkoxide with the dialkyl sulfate generated in the step (a) under reduced pressure in a second reactor to form a fluorine-containing ether compound. SELECTED DRAWING: Figure 1 COPYRIGHT: (C)2020,JPOandINPIT
Preparation method of hexafluoroisopropyl methyl ether
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Paragraph 0051-0074, (2019/06/30)
The invention discloses a preparation method of 1,1,1,3,3,3-hexafluoroisopropyl methyl ether. The preparation method includes reacting trifluoroacetate with formate to obtain 1,1,1,3,3,3-hexafluoroisopropanol, and applying a methylation reagent to the 1,1,1,3,3,3-hexafluoroisopropanol to obtain the 1,1,1,3,3,3-hexafluoroisopropyl methyl ether. The preparation method has the advantages that raw materials are cheap and easy to obtain, the preparation process is mild and the method is simple to operate.