1318242-98-6

Basic information

• Product Name: 4-aMinothieno[3,2-d]pyriMidine-7-carboxylic acid
• Synonyms: 4-aMinothieno[3,2-d]pyriMidine-7-carboxylic acid
• CAS NO: 1318242-98-6
• Molecular Formula: C7H5N3O2S
• Molecular Weight: 195.1985
• EINECS: -0
• Mol File: 1318242-98-6.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 512.9±45.0 °C(Predicted)
• Appearance: /
• Density: 1.707±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: -0.74±0.10(Predicted)
• CAS DataBase Reference: 4-aMinothieno[3,2-d]pyriMidine-7-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-aMinothieno[3,2-d]pyriMidine-7-carboxylic acid(1318242-98-6)
• EPA Substance Registry System: 4-aMinothieno[3,2-d]pyriMidine-7-carboxylic acid(1318242-98-6)

Safety Data

• Hazardous Substances Data: 1318242-98-6(Hazardous Substances Data)

Usage

General Description

4-Aminothieno[3,2-d]pyrimidine-7-carboxylic acid, also known as 7-ATP, is a chemical compound that belongs to the class of pyrimidine-based molecules. It contains a thieno ring fused to a pyrimidine ring and a carboxylic acid functional group at the 7th position. 4-Aminothieno[3,2-d]pyrimidine-7-carboxylic acid has potential applications in the field of medicinal chemistry, particularly in the development of novel pharmaceuticals and biologically active molecules. Its unique structure and properties make it a promising candidate for further research and investigation, with potential uses in drug discovery and development. Additionally, its aromatic and heterocyclic nature make it a useful building block for the synthesis of diverse chemical compounds, making it a valuable tool for organic synthesis.

Upstream product

• 22288-78-4 Methyl 3-aminothiophene-2-carboxylate 
• 31169-25-2 7-bromothieno[3,2-d]pyrimidine-4(3H)-one 
• 16234-10-9 3H-thieno[3,2-d]pyrimidin-4-one 
• 1446113-33-2 4-amino-thieno[3,2-d]pyrimidine-7-carbaldehyde 
• 1318132-91-0 7-vinylthieno[3,2-d]pyrimidine-4-amine 
• 1318133-32-2 7-bromothieno[3,2-d]pyrimidine-4-amine 
• 31169-27-4 7-bromo-4-chlorothieno[3,2-d]pyrimidine 

Downstream Products

• 1446111-75-6 4-amino-N-(4-((4-chlorophenyl)amino)-7-methylquinazolin-8-yl)thieno[3,2-d]pyrimidine-7-carboxamide 
• 1446111-86-9 4-amino-N-(6-methyl-1-phenoxyisoquinolin-5-yl)thieno[3,2-d]pyrimidine-7-carboxamide 
• 1446112-11-3 4-amino-N-(1-((4-chloro-3-((dimethylamino)methyl)phenyl)amino)-6-methylisoquinolin-5-yl)thieno[3,2-d]pyrimidine-7-carboxamide 
• 1446112-26-0 4-amino-N-(6-methyl-1-((3-(methylsulfonamido)phenyl)amino)isoquinolin-5-yl)thieno[3,2-d]pyrimidine-7-carboxamide 
• 1446112-28-2 tert-butyl 4-(5-((5-(4-aminothieno[3,2-d]pyrimidine-7-carboxamido)-6-methylisoquinolin-1-yl)amino)-2-chlorobenzyl)piperazine-1-carboxylate 
• 1446112-30-6 4-amino-N-(1-((4-chloro-3-(piperazin-1-ylmethyl)phenyl)amino)-6-methylisoquinolin-5-yl)thieno[3,2-d]pyrimidine-7-carboxamide hydrochloride 
• 1446111-26-7 4-amino-N-(1-((4-chlorophenyl)amino)-6-methylisoquinolin-5-yl)thieno[3,2-d]pyrimidine-7-carboxamide 

Relevant articles and documents

An Efficient Second-Generation Manufacturing Process for the pan-RAF Inhibitor Belvarafenib

Herein, the development of a streamlined manufacturing process for the pan-RAF inhibitor belvarafenib (GDC-5573) is reported. The process to belvarafenib features a number of efficient key reactions, including a robust and scalable Pd-catalyzed carbonylation reaction to generate thienopyrimidine 2 and a highly chemoselective Pt/V/C-catalyzed nitro group reduction to access the penultimate intermediate 3. The final amide coupling was accomplished by a mild and safe protocol employing N,N,N′,N′-tetramethylchloroformamidinium hexafluorophosphate as the coupling reagent, which afforded belvarafenib on a multikilogram production scale after recrystallization.

THIENO[3,2-D]PYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY FOR PROTEIN KINASES

Provided are a thieno[3,2-d]pyrimidine derivative of formula (I) or a pharmaceutically acceptable salt thereof having inhibitory activity for protein kinase, and a pharmaceutical composition comprising same for prevention and treatment of abnormal cell growth diseases.

THIENO[3,2-d]PYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY ON PROTEIN KINASES

The present invention relates to a thieno[3,2-d]pyrimidine derivative of formula (I), or a pharmaceutically acceptable salt, hydrate or solvate thereof, which has an excellent inhibitory activity on protein kinases, and a pharmaceutical composition comprising the same is effective in preventing or treating abnormal cell growth diseases.