13195-53-4

Basic information

• Product Name: 2-nitro-5-phenylsulfanyl-thiophene
• Synonyms: 2-nitro-5-phenylsulfanyl-thiophene
• CAS NO: 13195-53-4
• Molecular Weight: 237.303
• Mol File: 13195-53-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-nitro-5-phenylsulfanyl-thiophene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-nitro-5-phenylsulfanyl-thiophene(13195-53-4)
• EPA Substance Registry System: 2-nitro-5-phenylsulfanyl-thiophene(13195-53-4)

Safety Data

• Hazardous Substances Data: 13195-53-4(Hazardous Substances Data)

Upstream product

• 13195-50-1 2-bromo-5-nitrothiophene 
• 108-98-5 thiophenol 

Downstream Products

• 190967-12-5 N-(5-Phenylsulfanyl-thiophen-2-yl)-acetamide 

Relevant articles and documents

N-(5-Substituted) thiophene-2-alkylsulfonamides as potent inhibitors of 5-lipoxygenase

Compound 4k N-[5-(4-fluoro)phenoxythien-2-yl]methanesulfonamide is representative of a new class of potent inhibitors of 5-lipoxygenase (5-LO). These versatile compounds exhibit dose-dependent inhibition of 5-LO with IC50s ranging from 20-100 nM in the rat basophilic leukemia (RBL-1) cell homogenate assay and submicromolar IC50s in both the RBL-1 and human peripheral blood leukocyte (PBL) whole cell assays. Compound 4k also showed significant anti-inflammatory activity in the adjuvant arthritic rat at an oral dose of 3 mg/kg.