132095-53-5

Basic information

• Product Name: 5-Bromo-2-tetralone
• Synonyms: 5-BROMO-2-TETRALONE;5-Bromo-3,4-dihydro-1H-naphthalen-2-one;5-bromo-3,4-dihydronaphthalen-2(1H)-one;5-broMo-3;2(1H)-Naphthalenone,5-broMo-3,4-dihydro-
• CAS NO: 132095-53-5
• Molecular Formula: C₁₀H₉BrO
• Molecular Weight: 225.08
• Mol File: 132095-53-5.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 330.977 °C at 760 mmHg
• Flash Point: 117.027 °C
• Appearance: /
• Density: 1.511 g/cm³
• Vapor Pressure: 0.00016mmHg at 25°C
• Refractive Index: 1.598
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C
• CAS DataBase Reference: 5-Bromo-2-tetralone(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Bromo-2-tetralone(132095-53-5)
• EPA Substance Registry System: 5-Bromo-2-tetralone(132095-53-5)

Safety Data

• Hazardous Substances Data: 132095-53-5(Hazardous Substances Data)

Usage

Description

5-Bromo-2-tetralone is an organic compound with the molecular formula C10H9BrO. It is a derivative of tetralone, featuring a bromine atom at the 5th position and a ketone group at the 2nd position. 5-Bromo-2-tetralone is known for its potential applications in various fields due to its unique chemical structure and properties.

Uses

Used in Pharmaceutical Industry:
5-Bromo-2-tetralone is used as a reagent for the preparation of 2-aminotetralins, which are known for their high affinity and selectivity for the dopamine D3 receptor. This application is particularly relevant in the development of drugs targeting the dopaminergic system, which plays a crucial role in various neurological and psychiatric disorders, such as schizophrenia, Parkinson's disease, and addiction.

InChI:InChI=1/C10H9BrO/c11-10-3-1-2-7-6-8(12)4-5-9(7)10/h1-3H,4-6H2

Upstream product

• 74-85-1 ethene 
• 1878-67-7 3-Bromophenylacetic acid 
• 103-80-0 phenylacetyl chloride 
• 529-34-0 3,4-dihydronaphthalene-1(2H)-one 
• 92013-31-5 5-bromotetralol 
• 68449-30-9 5-bromo-1-tetralone 
• 87779-57-5 bromo-5 dihydro-3,4 naphthalene 
• 365555-15-3 4-(2-bromophenyl)-1-diazobutan-2-one 
• 15115-58-9 3-(2-bromophenyl)propionic acid 
• 90725-40-9 3-(2-bromophenyl)propanoyl chloride 

Downstream Products

• 1221135-69-8 C₁₈H₁₈BrNO 
• 183543-37-5 5-Cyano-N-(4-(4-phenylbenzoylamino)butyl)-2-(R,S)-propylamino-1,2,3,4-tetrahydronaphthalene 
• 183543-24-0 5-Bromo-N-(4-(4-phenylbenzoylamino)butyl)-2-(R,S)-propylamino-1,2,3,4-tetrahydronaphthalene 

Relevant articles and documents

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A glycine Schiff base Michael addition is used in sequence with free radical-mediated aryl amination to ultimately arrive at the ambiguine G ABC-tricycle convergently. Additionally, thermal Diels-Alder cycloaddition of β-chloromethacrolein with Cohen's di

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This invention relates to, in part, compositions and methods that are useful for, inter alia, the treatment of various diseases, including those linked to binding at a serotonin receptor in the Gl tract.

Structure-activity relationship of linear peptide Bu-His-DPhe-Arg-Trp-Gly-NH2 at the human melanocortin-1 and -4 receptors: Histidine substitution

Systematic substitution of His6 residue using non-selective hMC4R pentapeptide agonist (Bu-His6-DPhe7-Arg8-Trp9-Gly 10-NH2) as the template led to the identification of Bu-Atcsu