132114-36-4Relevant articles and documents
SYNTHESIS OF γ-LACTAM ANALOGUES OF 1-ACETOXY CARBAPENEM DERIVATIVES
Coulton, S.,Francois, I.,Southgate, R.
, p. 6923 - 6926 (1990)
The syntheses of γ-lactam analogues of the 1-acetoxy carbapenem esters, from dl-pyroglutamic acid are described.Attempted deprotection to provide the free carboxylic acids resulted in degradation.Whilst the free acid of the 1-hydroxy carbapenem analogue was chemically stable, it lacked antibacterial activity.