132294-22-5

Basic information

• Product Name: 1,2-Cyclobutanedimethanol,3,3-diethoxy-,(1R-trans)-(9CI)
• Synonyms: 1,2-Cyclobutanedimethanol,3,3-diethoxy-,(1R-trans)-(9CI)
• CAS NO: 132294-22-5
• Molecular Formula: C₁₀H₂₀O₄
• Molecular Weight: 204.26
• Product Categories: ETHOXY
• Mol File: 132294-22-5.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1,2-Cyclobutanedimethanol,3,3-diethoxy-,(1R-trans)-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Cyclobutanedimethanol,3,3-diethoxy-,(1R-trans)-(9CI)(132294-22-5)
• EPA Substance Registry System: 1,2-Cyclobutanedimethanol,3,3-diethoxy-,(1R-trans)-(9CI)(132294-22-5)

Safety Data

• Hazardous Substances Data: 132294-22-5(Hazardous Substances Data)

Usage

Stereoisomer

1,2-cyclobutanedimethanol,3,3-diethoxy-,(1S-trans)-(9CI)
It is a stereoisomer of the mentioned compound, having the same molecular formula but a different spatial arrangement of atoms.

Derivative

Cyclobutane
The compound is derived from cyclobutane, a four-membered cyclic hydrocarbon.

Functional groups

Two methanol and two diethoxy groups
The compound contains two methanol (alcohol) groups and two diethoxy (ether) groups.

Application

Organic synthesis and pharmaceuticals
It is commonly used in organic synthesis and as a building block for the preparation of various pharmaceuticals and fine chemicals.

Physical state

Colorless liquid
The compound appears as a colorless liquid at room temperature.

Molecular weight

204.26 g/mol
The molecular weight of the compound is 204.26 grams per mole.

Boiling point

220-221°C at 760 mmHg
The compound boils at a temperature range of 220-221°C under a pressure of 760 mmHg (standard atmospheric pressure).

Upstream product

• 2032-35-1 Bromoacetaldehyde diethyl acetal 
• 2678-54-8 ketene diethyl acetal 
• 127696-10-0 trans-3,3-diethoxy-1,2-cyclobutanedicarboxylic acid diethyl ester 
• 216321-55-0 (1R,2S)-3,3-diethoxycyclobutane-1,2-dicarboxylic acid methyl ester 
• 132294-21-4 <1R-<1α(R^*),2β(R^*)>>-3,3-diethoxy-N,N'-bis-(2-hydroxy-1-phenylethyl)-1,2-cyclobutanedicarboxamide 
• 132294-29-2 (1R,2S)-3,3-Diethoxy-cyclobutane-1,2-dicarboxylic acid bis-{[(R)-2-(tert-butyl-dimethyl-silanyloxy)-1-phenyl-ethyl]-amide} 
• 132178-71-3 trans-3,3-diethoxy-1,2-cyclobutanedicarboxylic acid 
• 132294-30-5 C₃₈H₆₀N₄O₈Si₂ 

Downstream Products

• 142343-76-8 (+)-(1R,2S,3S)-2,3-bis<(benzyloxy)methyl>cyclobutylamine 
• 132164-72-8 trans-2,3-bis<(benzyloxy)methyl>cyclobutanone 
• 142343-72-4 (+)-(1S,2S,3S)-2,3-bis<(benzyloxy)methyl>-1-cyclobutyl acetate 
• 142343-75-7 C₂₀H₂₃N₃O₂ 
• 142343-74-6 (+)-(1S,2S,3S)-2,3-bis<(benzyloxy)methyl>-1-cyclobutyl tosylate 
• 142343-77-9 (+)-(1R,2S,3S)-2-amino-7-<2,3-bis<(benzyloxy)methyl>cyclobutyl>-4-chloropyrrolo<2,3-d>-pyrimidine 
• 142343-78-0 (+)-(1R,2S,3S)-2-amino-7-<2,3-bis<(benzyloxy)methyl>cyclobutyl>pyrrolo<2,3-d>-pyrimidin-4(3H)-one 
• 142343-73-5 (-)-(1R,2R,3R)-2,3-bis<(benzyloxy)methyl>-1-cyclobutanol 
• 142434-69-3 (+)-(1S,2S,3S)-2,3-bis<(benzyloxy)methyl>-1-cyclobutanol 
• 142343-73-5 (+/-)-(1α,2α,3β)-2,3-bis<(benzyloxy)methyl>cyclobutanol 
• 126261-73-2 C₂₀H₂₀O₅ 
• 124770-80-5 trans-2,3-bis(benzoyloxymethyl)cyclobutanone 

Relevant articles and documents

CYCLOBUTYL NUCLEOSIDE ANALOGS AS ANTI-VIRALS

Described herein are cyclobutyl nucleoside analogs of Formula (I), pharmaceutical compositions that include one or more cyclobutyl nucleoside analogs and methods of using the same to treat HBV, HDV and/or HIV.

Synthetic studies toward providencin: Efficient construction of a furanyl-cyclobutanone fragment

Described is the construction of a furanyl-cylcobutanone fragment suited for incorporation into a synthesis of the naturally occurring anti-cancer agent Providencin.

Synthesis of SQ-33,054, a novel cyclobutane nucleoside with potent antiviral activity

The racemic, guanine-containing cyclobutane nucleoside SQ-33,054 (3) was synthesized in 8 steps from the cyclobutane diester 4.