1323137-10-5Relevant articles and documents
Highly active well-defined palladium precatalysts for the efficient amination of aryl chlorides
Chartoire, Anthony,Lesieur, Mathieu,Slawin, Alexandra M. Z.,Nolan, Steven P.,Cazin, Catherine S. J.
, p. 4432 - 4436 (2011/10/10)
The efficient preparation of [Pd(Amphos)(cinnamyl)Cl)] and [Pd(Amphos)(TFA)(κ2-N,C-C6H4-CH 2NMe2)] (Amphos = 4-(di-tert-butylphosphino)-N,N- dimethylaniline and TFA = trifluoroacetate), two new well-defined palladium precatalysts, is reported. These complexes prove highly active in the Buchwald-Hartwig amination reaction, allowing the coupling of a wide range of (hetero)aryl chlorides, including unactivated, neutral, and sterically hindered substrates, with a wide range of amines, including primary and secondary amines. Finally, the catalytic systems have proven efficient at low catalyst loadings ranging from 0.1 to 0.3 mol %.