132353-25-4

Basic information

• Product Name: Benzoic acid, 4-methoxy-, 4,6-dimethoxy-1,3,5-triazin-2-yl ester
• CAS NO: 132353-25-4
• Molecular Formula: C13H13N3O5
• Molecular Weight: 291.263
• Mol File: 132353-25-4.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 4-methoxy-, 4,6-dimethoxy-1,3,5-triazin-2-yl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 4-methoxy-, 4,6-dimethoxy-1,3,5-triazin-2-yl ester(132353-25-4)
• EPA Substance Registry System: Benzoic acid, 4-methoxy-, 4,6-dimethoxy-1,3,5-triazin-2-yl ester(132353-25-4)

Safety Data

• Hazardous Substances Data: 132353-25-4(Hazardous Substances Data)

Upstream product

• 3140-73-6 2-chloro-4,6-dimethoxy-1 ,3,5-triazine 
• 100-09-4 4-methoxybenzoic acid 
• 3945-69-5 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride 
• 63910-63-4 bis(4,6-dimethoxy-1,3,5-triazin-2-yl) ether 

Downstream Products

• 39192-94-4 N-(p-methylphenyl)-p-methoxybenzamide 
• 93709-64-9 (S)-2-(4-methoxybenzamido) propanoic acid 
• 77876-73-4 2-(4-methoxyphenyl)-4-methyl-5-phenyloxazole 
• 123-11-5 4-methoxy-benzaldehyde 
• 611-94-9 4-Methoxybenzophenone 
• 1075-59-8 2-hydroxy-4,6-dimethoxy-1,3,5-triazine 
• 603126-31-4 1-(4-methoxyphenyl)-2-nonyn-1-one 
• 93845-81-9 1-(4-methoxyphenyl)hept-2-yn-1-one 
• 65418-73-7 1-(4-methoxyphenyl)-3-(4-bromophenyl)-2-ethynyl-1-one 
• 65418-72-6 1-(4-methoxyphenyl)-3-(4-methylphenyl)-2-ethynyl-1-one 
• 16616-43-6 1-(4-methoxy-phenyl)-3-phenyl-propynone 
• 65418-71-5 1,3-bis-(4-methoxyphenyl)-2-ethynyl-1-one 
• 3140-73-6 2-chloro-4,6-dimethoxy-1 ,3,5-triazine 
• 36364-17-7 5-(4-methoxyphenyl)-3-phenyl-1,2,4-oxadiazole 

Relevant articles and documents

The design, synthesis, and application of a chiral coupling reagent derived from strychnine for the enantioselective activation of a carboxylic group

The concept of a chiral coupling reagent for the enantioselective synthesis of peptides with a predictable configuration and enantiomeric purity from racemic substrates is presented. The reagent was prepared by treatment of strychninium tetrafluoroborate with 2-chloro-4,6-dimethoxy-1,3,5-triazine in the presence of sodium bicarbonate yielding N-(4,6-dimethoxy-1,3,5-triazin-2-yl)strychninium tetrafluoroborate in high yield, which is stable at room temperature, and in a broad range of solvents gave enriched Z-Ala-Phe-OMe (dr from 95/5 to 60/40) in high yield with d-configuration on the alanine residue starting from rac-Z-Ala-OH.

A Strategy for Accessing Aldehydes via Palladium-Catalyzed C?O/C?N Bond Cleavage in the Presence of Hydrosilanes

We report the catalytic reduction of both active esters and amides by selective C(acyl)?X (X=O, N) cleavage to access aldehyde functionality via a palladium-catalyzed strategy. Reactions are promoted by hydrosilanes as reducing reagents with good to excellent yields and with excellent chemoselectivity for C(acyl)?N and C(acyl)?O bond cleavage. Carboxylic acid C(acyl)?O bonds are activated by 2-chloro-4,6-dimethoxy-1,3,5-triazine (CDMT) to form triazine ester intermediates, which further react with hydrosilanes to yield aldehydes in one-pot two-step procedures. We demonstrate that C(acyl)?O cleavage/formylation offers higher yields and broader substrate scopes compared with C(acyl)?N cleavage under the same reaction conditions.

One-Pot Synthesis of Arylketones from Aromatic Acids via Palladium-Catalyzed Suzuki Coupling

A palladium-catalyzed one-pot procedure for the synthesis of aryl ketones has been developed. Triazine esters when coupled with aryl boronic acids provided aryl ketones in moderate to excellent yields (up to 95%) in the presence of 1 mol % Pd(PPh3)2Cl2 for 30 min. (Chemical Equation Presented).