132388-67-1

Basic information

• Product Name: Fmoc-Gln(Trt)-ODhbt
• CAS NO: 132388-67-1
• Molecular Weight: 755.83
• Mol File: 132388-67-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Fmoc-Gln(Trt)-ODhbt(CAS DataBase Reference)
• NIST Chemistry Reference: Fmoc-Gln(Trt)-ODhbt(132388-67-1)
• EPA Substance Registry System: Fmoc-Gln(Trt)-ODhbt(132388-67-1)

Safety Data

• Hazardous Substances Data: 132388-67-1(Hazardous Substances Data)

Upstream product

• 132388-60-4 (S)-2-(((benzyloxy)carbonyl)amino)-5-oxo-5-(tritylamino)pentanoic acid 
• 102747-84-2 5-trityl-L-glutamine 
• 56-85-9 L-glutamine 
• 76-84-6 triphenylmethyl alcohol 
• 132327-80-1 Fmoc-L-Gln(Trt)-OH 
• 28230-32-2 3-hydroxy-3,4-dihydrobenzotriazine-4-one 

Relevant articles and documents

Protection of carboxamide functions by the trityl residue. Application to peptide synthesis

Carboxamide functions may be tritylated by an acid-catalyzed reaction with triphenylmethanol and acetic anhydride in glacial acetic acid. The ω-trityl group of asparagine and glutamine is cleavable by TFA, but stable to strong mineral acids in aqueous solution, as well as to nucleophiles and bases. In peptide syntheses, it is ideally suited for combination with side-chain protections of the t.butyl-type.