13241-33-3

Basic information

• Product Name: Neohesperidin
• Synonyms: Neohesperidin HPLC 96% Min;Neohesperidin≥ 98% (HPLC);(s)-a-d-glucopyranosyl)oxy)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl);4h-1-benzopyran-4-one,2,3-dihydro-7-((2-o-(6-deoxy-alpha-l-mannopyranosyl)-bet;HESPERETIN-7-NEOHESPERIDOSIDE;HESPERETIN-7-O-NEOHESPERIDOSIDE;(S)-7-(((2-O-6-Deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-2,3-dihydro-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one;(S)-4'-METHOXY-3',5,7-TRIHYDROXYFLAVONE-7-[2-O-(ALPHA-L-RHAMNOPYRANOSYL)-BETA-D-GLUCOPYRANOSIDE]
• CAS NO: 13241-33-3
• Molecular Formula: C₂₈H₃₄O₁₅
• Molecular Weight: 610.56
• EINECS: 236-216-9
• Product Categories: Inhibitors;Flavanones;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract
• Mol File: 13241-33-3.mol
• Article Data: 0

Chemical Properties

• Melting Point: 239-243°C
• Boiling Point: 933.7 ºC at 760 mmHg
• Flash Point: 306.7 ºC
• Appearance: /
• Density: 1.65 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.695
• Storage Temp.: 2-8°C
• Solubility: DMSO (Slightly), Pyridine (Slightly)
• PKA: 7.14±0.40(Predicted)
• Water Solubility: 3.98mg/L at 20℃
• BRN: 74945
• CAS DataBase Reference: Neohesperidin(CAS DataBase Reference)
• NIST Chemistry Reference: Neohesperidin(13241-33-3)
• EPA Substance Registry System: Neohesperidin(13241-33-3)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• RTECS: DJ2981400
• F: 10-21
• Hazardous Substances Data: 13241-33-3(Hazardous Substances Data)

Usage

Description

Neohesperidin is a flavonoid found in citrus fruit peel that has diverse biological activities. In vitro, it inhibits osteoclast differentiation, bone resorption, calcium oscillations, and activation of NF-κB and nuclear factor of activated T cells (NFAT) by receptor activator of NF-κB ligand (RANKL). In vivo, neohesperidin administration protects ovariectomized mice from bone loss. Neohesperidin acts as a hypolipidemic agent, reducing lipid accumulation in HepG2 cells and reversing hyperlipidemia in a mouse model of diet-induced obesity. In a mouse model of diabetes, neohesperidin increases glucose tolerance and decreases insulin resistance while simultaneously decreasing serum triglycerides and total cholesterol and inhibiting lipid accumulation in livers in vivo.

Chemical Properties

White powder

Uses

Different sources of media describe the Uses of 13241-33-3 differently. You can refer to the following data:
1. Neohesperidin can be used in cosmetic products and as a sweetening agent in food & beverages, an antioxidant flavanone glycoside
2. An antioxidant flavanone glycoside
3. Neohesperidin exhibits lipid-regulating effects in vivo and in vitro. It is a main flavonoid in citrus byproducts (CBP) which possesses anti-oxidant activity.

Definition

ChEBI: A flavanone glycoside that is hesperitin having an 2-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranosyl moiety attached to the 7-hydroxy group.

Flammability and Explosibility

Notclassified

InChI:InChI=1/C28H34O15/c1-10-21(33)23(35)25(37)27(39-10)43-26-24(36)22(34)19(9-29)42-28(26)40-12-6-14(31)20-15(32)8-17(41-18(20)7-12)11-3-4-16(38-2)13(30)5-11/h3-7,10,17,19,21-31,33-37H,8-9H2,1-2H3/t10-,17-,19+,21-,22+,23+,24-,25+,26+,27-,28+/m0/s1

Downstream Products

• 552-58-9 eriodictyol 
• 502764-74-1 6''-O-lauroyl neohesperidin 
• 20702-77-6 neohesperidin 
• 19949-48-5 2-O-α-L-rhamnopyranosyl-β-D-glucopyranose 
• 520-33-2 hesperetin 
• 38665-01-9 4′-O-methylluteolin-7-O-rhamnoglucoside