132482-05-4

Basic information

• Product Name: (R)-METHYL 2-(PYRROLIDIN-2-YL)ACETATE
• Synonyms: (R)-METHYL 2-(PYRROLIDIN-2-YL)ACETATE;(R)-tert-Butyl 2-(2-Methoxy-2-oxoethyl)pyrrolidine-1-carboxylate
• CAS NO: 132482-05-4
• Molecular Formula: C₁₂H₂₁NO₄
• Molecular Weight: 143.185
• Mol File: 132482-05-4.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 190.215°C at 760 mmHg
• Flash Point: 68.84°C
• Appearance: /
• Density: 1.006g/cm³
• Vapor Pressure: 0.548mmHg at 25°C
• Refractive Index: 1.44
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (R)-METHYL 2-(PYRROLIDIN-2-YL)ACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-METHYL 2-(PYRROLIDIN-2-YL)ACETATE(132482-05-4)
• EPA Substance Registry System: (R)-METHYL 2-(PYRROLIDIN-2-YL)ACETATE(132482-05-4)

Safety Data

• Hazardous Substances Data: 132482-05-4(Hazardous Substances Data)

Usage

General Description

(R)-Methyl 2-(pyrrolidin-2-yl)acetate, also known as R-MA, is a chemical compound with the molecular formula C8H13NO2. It is an ester derived from the amino acid proline and has a pyrrolidine ring structure. (R)-METHYL 2-(PYRROLIDIN-2-YL)ACETATE has been studied for its potential use in pharmaceuticals and as a chiral building block in organic synthesis. It has also been investigated for its potential use in the development of new drug candidates and as a precursor for the synthesis of natural products. However, further research is needed to fully understand the potential applications and effects of (R)-Methyl 2-(pyrrolidin-2-yl)acetate.

InChI:InChI=1/C7H13NO2/c1-10-7(9)5-6-3-2-4-8-6/h6,8H,2-5H2,1H3/t6-/m1/s1

Upstream product

• 186581-53-3 diazomethane 
• 67-56-1 methanol 
• 84890-94-8 (S)-2-Isobutoxycarbonyloxycarbonyl-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 101555-60-6 2-(R)-carboxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 86971-65-5 pyrrolidin-2-ylidene-acetic acid methyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 
• 813433-68-0 2-methoxycarbonylmethylpyrrolidine-1-carboxylic acid tert-butyl ester 
• 56502-01-3 (2S)-1-tert-butoxycarbonyl-2-carboxymethylpyrrolidine 
• 259868-83-2 (S)-pyrrolidin-2-ylacetic acid methyl ester hydrochloride 
• 141874-26-2 N-Boc-(S)-proline chloride 
• 15761-39-4 1-(tert-butoxycarbonyl)-L-proline 
• 101130-03-4 tert-butyl (S)-2-(diazoacetyl)pyrrolidine-1-carboxylate 
• 344-25-2 D-Prolin 

Downstream Products

• 61810-78-4 (-)-2-((S)-1-methylpyrrolidin-2-yl)ethanol 
• 88790-38-9 (2S)-tert-butyl 2-(2-hydroxyethyl)pyrrolidine-1-carboxylate 
• 53912-83-7 [(2S)-pyrrolidin-2-yl]acetic acid methyl ester 
• 340040-67-7 methyl 2-[(2R)-pyrrolidin-2-yl]acetate hydrochloride 
• 201038-72-4 (R)-1-(2-(1-(3-benzyloxy-benzenesuylfonyl)-pyrrolidin-2-yl)-ethyl)-4-methyl piperidine 
• 261901-57-9 SB 269970 A 
• 1338968-17-4 C₂₉H₄₁NO₃ 
• 1178977-16-6 (S)-1,1-bis(4-propylphenyl)-2-(pyrrolidin-2-yl)ethanol 
• 1338968-19-6 C₃₃H₄₉NO₃ 
• 1178977-17-7 (S)-1,1-bis(4-pentylphenyl)-2-(pyrrolidin-2-yl)ethanol 
• 1338968-20-9 C₂₇H₂₅F₁₂NO₃ 
• 1178977-14-4 (S)-1,1-bis(3,5-bis(trifluoromethyl)phenyl)-2-(pyrrolidin-2-yl)ethanol 
• 1178977-11-1 (S)-1,1-diphenyl-2-(pyrrolidin-2-yl)ethanol 
• 1338968-21-0 C₁₉H₂₁NO₂ 

Relevant articles and documents

LIGAND EFFECTS IN ENANTIOFACE DIFFERENTIATING 1,4 ADDITION TO 1,3 DIPHENYL-2 PROPEN-1 ONE

The extent of enantiomeric excess in the β-methylation of chalcone by chiral cuprates is shown to depend strongly on small structural modifications of the ligands, all of which are derived from the basic carbon framework of L-prolinol.Enantiomeric excesses up to 88percent have been realised.

Diastereoselective synthesis of (-)-1-methyl-(3S,4R)-3,4-bis((2S)-N- (tert-butyloxycarbonyl)pyrrolidin-2-yl)-2-pyrrolidinone by an asymmetric Michael reaction

Beginning with enantiomerically pure L-proline, (-)-1-methyl-(3S,4R)- 3,4-bis((2S)-N-(tert-butyloxycarbonyl)pyrrolidin-2-yl)-2-pyrrolidinone was prepared in diastereomerically pure form. Taking advantage of the chiral induction of the L-proline derivatives, the intermolecular Michael reaction, used to build the pyrrolidinone ring, was carried out stereoselectively.

Iminium ion-enamine cascade cyclizations: Facile access to structurally diverse azacyclic compounds and natural products

A one-pot, mild, two-component iminium ion-enamine cascade reaction to construct structurally diverse azacyclic frameworks from l-proline and l-pipecolic acid, and its application to indolizidine and quinolizidine alkaloids and azasteroids, is reported.

Kinetic deconjugation: A gateway to the synthesis of Xxx-Gly (E)-alkene dipeptide isosteres

A new method for the preparation of Xxx-Gly (E)-alkene dipeptide isosteres (EADIs), using LDA deprotonation followed by 1 N HCl quench, was explored. The method, named kinetic deconjugation, enabled the synthesis of Tyr-Gly, Gly-Gly, Ser-Gly, Pro-Gly, and