1325724-92-2

Basic information

• Product Name: 1-(3,4-dichlorophenyl)-1H-1,2,3-triazole-4-carbaldehyde
• Synonyms: 1-(3,4-dichlorophenyl)-1H-1,2,3-triazole-4-carbaldehyde
• CAS NO: 1325724-92-2
• Molecular Weight: 242.064
• Mol File: 1325724-92-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1-(3,4-dichlorophenyl)-1H-1,2,3-triazole-4-carbaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3,4-dichlorophenyl)-1H-1,2,3-triazole-4-carbaldehyde(1325724-92-2)
• EPA Substance Registry System: 1-(3,4-dichlorophenyl)-1H-1,2,3-triazole-4-carbaldehyde(1325724-92-2)

Safety Data

• Hazardous Substances Data: 1325724-92-2(Hazardous Substances Data)

Upstream product

• 107-19-7 propargyl alcohol 
• 95-76-1 m,p-dichloroaniline 
• 66172-16-5 4-azido-1,2-dichlorobenzene 
• 338419-11-7 1-(3,4-dichlorophenyl)-1H-1,2,3-triazole-4-yl-methanol 

Downstream Products

• 1325725-23-2 1-(3,4-dichlorophenyl)-4-vinyl-1H-1,2,3-triazole 

Relevant articles and documents

Design, synthesis and biological evaluation of 1H-1,2,3-triazole-linked- 1H-dibenzo[b,h]xanthenes as inductors of ROS-mediated apoptosis in the breast cancer cell line MCF-7

Background: Low molecular weight 1,2,3-triazoles and naphthoquinones are endowed with various types of biological activity, such as against cancer, HIV and bacteria. However, in some cases, the conjugation of these two nuclei considerably increases their biological activities. Objective: In this work, we decided to study the synthesis and screening of bis-naphthoquinones and xanthenes tethered to 1,2,3-triazoles against cancer cell lines, specifically the human breast cancer cell line MCF-7. Results: Starting from lawsone and aryl-1H-1,2,3-triazole-4-carbaldehydes (10a-h) several new 7- (1-aryl-1H-1,2,3-triazol-4-yl)-6H-dibenzo[b,h]xanthene-5,6,8,13(7H)-tetraones (12a-h) and 3,3'- ((1-aryl-1H-1,2,3-triazol-4-yl)methylene)bis(2-hydroxynaphthalene-1,4-diones) 11a-h were synthesized and evaluated for their cytotoxic activities using the human breast cancer cell line MCF-7 and the non-tumor cell line MCF10A as control. We performed test of cell viability, cell proliferation, intracellular ATP content and cell cytometry to determine reactive oxygen species (ROS) formation. Conclusions: Based on these results, we found that compound 12a promotes ROS production, interfering with energy metabolism, cell viability and proliferation, and thus promoting whole cell damage.

Design and synthesis of novel dehydroepiandrosterone analogues as potent antiproliferative agents

The aim of the present study was to determine the cytotoxic effects of a series of novel dehydroepiandrosterone derivatives containing triazole at the C16 position on human cancer cells. The cancer cells used in the present study were A549, Hel