132605-96-0

Basic information

• Product Name: Boc-(R)-2-(aMinoMethyl)-4-Methylpentanoic acid
• Synonyms: Boc-(R)-2-(aMinoMethyl)-4-Methylpentanoic acid;(Tert-Butoxy)Carbonyl (R)-2-(Aminomethyl)-4-methylpentanoic acid;Pentanoic acid,2-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-4-methyl-, (2R)-
• CAS NO: 132605-96-0
• Molecular Formula: C12H23NO4
• Molecular Weight: 245.31532
• Mol File: 132605-96-0.mol
• Article Data: 7

Chemical Properties

• Melting Point: 74 °C(Solv: ethyl ether (60-29-7); pentane (109-66-0))
• Boiling Point: 374.3±25.0 °C(Predicted)
• Appearance: /
• Density: 1.046±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 4.49±0.21(Predicted)
• CAS DataBase Reference: Boc-(R)-2-(aMinoMethyl)-4-Methylpentanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: Boc-(R)-2-(aMinoMethyl)-4-Methylpentanoic acid(132605-96-0)
• EPA Substance Registry System: Boc-(R)-2-(aMinoMethyl)-4-Methylpentanoic acid(132605-96-0)

Safety Data

• Hazardous Substances Data: 132605-96-0(Hazardous Substances Data)

Usage

General Description

Boc-(R)-2-(aminomethyl)-4-methylpentanoic acid is a chemical compound commonly used in organic synthesis and pharmaceutical research. It is a derivative of the amino acid valine, with a tert-butoxycarbonyl (Boc) protecting group attached to the amino group. Boc-(R)-2-(aMinoMethyl)-4-Methylpentanoic acid is often employed as a building block in the preparation of peptide and protein-based drugs, as well as in the synthesis of other complex organic molecules. Its chiral nature, with a stereocenter at the R position, makes it useful for the production of enantiopure compounds. Boc-(R)-2-(aminomethyl)-4-methylpentanoic acid is also known for its stability and compatibility with a wide range of chemical reactions, making it a valuable tool in organic synthesis and drug discovery.

Upstream product

• 61-90-5 L-leucine 
• 28659-87-2 (S)-2-bromo-4-methylpentanoic acid 
• 776327-14-1 2-aminomethyl-4-methyl-pentanoic acid methyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 
• 941292-90-6 (S)-β-2-methylpropyl-γ-Boc-amino-propylalcohol 
• 106367-47-9 Methyl 4-methyl-2-cyanopent-2-enoate 
• 132605-95-9 2-(aminomethyl)-4-methylpentanoic acid hydrochloride 
• 114438-66-3 (-)-methyl-(S)-2-bromo-4-methylpentanoate 
• 887143-09-1 methyl 2-[(dibenzylamino)methyl]-4-methylpentanoate 
• 100869-07-6 2-(aminomethyl)-4-methylpentanoic acid 
• 262301-37-1 N-[3-(N'-diphenylmethylene)-2-isobutylaminopropionyl] sultam 
• 887143-14-8 (2S)-N-{(2R)-2-[(dibenzylamino)methyl]-4-methylpentanoyl}camphorsultam 
• 927830-83-9 (R)-2-Aminomethyl-1-((1R,5S,7S)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-4-methyl-pentan-1-one 
• 887143-13-7 (S)-N-(2-bromo-4-methyl-pentanoyl) camphorsultam 

Relevant articles and documents

Beta amino acid-modified and fluorescently labelled kisspeptin analogues with potent KISS1R activity

Kisspeptin analogues with improved metabolic stability may represent important ligands in the study of the kisspeptin/KISS1R system and have therapeutic potential. In this paper we assess the activity of known and novel kisspeptin analogues utilising a du

New scalable asymmetric aminomethylation reaction for the synthesis of β2-amino acids

β-Amino acids are useful tools in the design of peptidomimetics, and the development of new methods for their syntheses, particularly the synthesis of β2-amino acids, remains an important challenge. Here we report a new scalable route based on the aminomethylation of silyl ketene N,O-acetals by Mannich-type iminium electrophiles. Wiley-VCH Verlag GmbH & Co. KGaA, 2007.

CONCISE BETA2-AMINO ACID SYNTHESIS VIA ORGANOCATALYTIC AMINOMETHYLATION

The present invention provides a method for the synthesis of ?2-amino acids. The method also provides methods yielding a-substituted ?-amino aldehydes and ?-substituted γ-amino alcohols. The present method according to this invention allows for increased yield and easier purification using minimal chromatography or crystallization. The methods described herein are based on an aldehyde aminomethylation which involves a Mannich reaction between an aldehyde and a formaldehyde-derived N,O-acetal (iminium precursor) and a catalyst, such as, for example, L-proline or a pyrrolidine. The invention allows for large scale, commercial preparation of ?2-amino acids.