132898-81-8

Basic information

• Product Name: 3-Pyridinecarbonitrile, 2-ethynyl- (9CI)
• Synonyms: 3-Pyridinecarbonitrile, 2-ethynyl- (9CI);2-ethynylnicotinonitrile
• CAS NO: 132898-81-8
• Molecular Formula: C₈H₄N₂
• Molecular Weight: 128.13076
• Product Categories: PYRIDINE
• Mol File: 132898-81-8.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-Pyridinecarbonitrile, 2-ethynyl- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Pyridinecarbonitrile, 2-ethynyl- (9CI)(132898-81-8)
• EPA Substance Registry System: 3-Pyridinecarbonitrile, 2-ethynyl- (9CI)(132898-81-8)

Safety Data

• Hazardous Substances Data: 132898-81-8(Hazardous Substances Data)

Usage

Uses

2-Ethynylnicotinonitrile can be used as Hsp90 inhibitors as an anti-cancer metastasis drugs.

Upstream product

• 6602-54-6 2-chloro-3-pyridinecarbonitrile 
• 1066-54-2 trimethylsilylacetylene 
• 97308-49-1 2-trimethylsilylethynyl-3-pyridinecarbonitrile 

Downstream Products

• 132898-86-3 6-((R)-1-Phenyl-ethyl)-7,8-dihydro-6H-[1,6]naphthyridin-5-one 
• 132898-84-1 2-[2-((R)-1-Phenyl-ethylamino)-ethyl]-nicotinonitrile 
• 132898-88-5 1-Methyl-6-((R)-1-phenyl-ethyl)-4,6,7,8-tetrahydro-1H-[1,6]naphthyridin-5-one 
• 138850-44-9 1-Methyl-6-<(S)-1-benzylhydroxyethyl>-5-oxo-5,6,7,8-tetrahydro-1,6-naphthyridinium iodide 
• 132898-89-6 1-Methyl-6-<(S)-1-benzylhydroxyethyl>-1,4,5,6,7,8-hexahydro-5-oxo-1,6-naphthyridine 
• 138921-62-7 2-<2-(N-(S)-1-benzylhydroxyethyl)amino>ethenylnicotinonitrile 

Relevant articles and documents

1,3-Dipolar cycloaddition of azomethine imines to ethynyl hetarenes: A synthetic route to 2,3-dihydropyrazolo[1,2-a]pyrazol-1(5H)-one based heterobiaryls

π-Deficient ethynyl hetarenes were used as dipolarophiles in a 1,3-dipolar cycloaddition reaction with azomethine imines (2-arylidene-5-oxopyrazolidin-2-ium-1-ides). Both CuI-catalyzed and catalyst-free thermally induced reactions proceeded with high regioselectivity providing 6-hetaryl-5-aryl-2,3-dihydropyrazolo[1,2-a]pyrazol-1(5H)-ones in moderate to excellent yields. The ethynyl hetarenes (pyridines, pyrazines, quinoxalines, pteridines and pyrimido[4,5-c]pyridazines) with ortho-methyl, ortho-cyano and ortho-alkynyl substituents were applicable to this reaction. 1,3-Dipolar cycloaddition reactions of alkynyl hetarenes with azomethine imines or other 1,3-dipole reagents can be considered as an alternative synthetic approach to heterobiaryls.

Asymmetric Reductions with Freely and Non-freely Rotating Amide Group NADH Models

NADH models with a freely or a non freely rotating chiral amide group have been synthesized and used in the reduction of methyl benzoylformate.The same major enantiomer was obtained in all cases.A blocked reagent bearing a phenylalaninol group as chiral auxiliary allows one to obtain a high e.e.