133040-03-6Relevant articles and documents
DUAL-ACTING ANTIHYPERTENSIVE AGENTS
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Page/Page column 39, (2010/02/17)
In one aspect, the invention relates to compounds having the formula: wherein: Ar, r, Z, X, R3, and R5-7 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have AT1 receptor antagonist activity and neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.
IMPROVED PROCESS FOR EPROSARTAN
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Page/Page column 6-7, (2008/12/06)
The present invention provides an improved and commercially viable process for preparation of eprosartan and its pharmaceutically acceptable acid addition salts thereof in high purity and in high yield. Thus, for example, methyl 4-[[2-butyl-5-formyl-1 H-i
Synthesis and angiotensin II antagonist activity of novel 2-arylthio-3-(2-alkyl-1-(4-carboxybenzyl)imidazolyl)acrylic acids
Shafiee,Hadizadeh,Karimi,Mahmoudian,Razzaghi
, p. 535 - 538 (2007/10/03)
A series of 2-arylthio-3-(2-alkyl-1-(4-carboxybenzyl)imidazolyl)acrylic acids were synthesized and evaluated as angiotensin II antagonists on guinea-pig ileal smooth muscle. 2-Phenylthio-3-(2-n-butyl-1-(4-carboxybenzyl)imidazolyl) acrylic acid was found t