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133083-36-0

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133083-36-0 Usage

Description

N'-(tert-Butoxycarbonyl)-N-(9-fluorenylmethyloxycarbonyl)-D-lysine pentafluorophenyl ester is a chemical compound specifically designed for use in peptide synthesis. It is a modified derivative of the amino acid lysine, featuring a tert-butyloxycarbonyl group and a fluorenylmethyloxycarbonyl group for protection, along with a pentafluorophenyl ester for activation. These structural modifications facilitate the compound's incorporation into peptides during the synthesis process, with the ability to be removed once the peptide synthesis is complete. N'-(tert-Butoxycarbonyl)-N-(9-fluorenylmethyloxycarbonyl)-D-lysine pentafluorophenyl ester is widely utilized in research and pharmaceutical applications for the creation of custom peptides, which can be employed for studying protein structures or for the development of novel therapeutic agents.

Uses

Used in Peptide Synthesis:
N'-(tert-Butoxycarbonyl)-N-(9-fluorenylmethyloxycarbonyl)-D-lysine pentafluorophenyl ester is used as a protected amino acid in peptide synthesis for the incorporation of D-lysine residues. The protection groups ensure that the lysine side chain does not participate in unwanted side reactions during the synthesis process, while the pentafluorophenyl ester group enhances the reactivity of the compound, allowing for efficient coupling with other peptide fragments.
Used in Research Applications:
In the field of research, N'-(tert-Butoxycarbonyl)-N-(9-fluorenylmethyloxycarbonyl)-D-lysine pentafluorophenyl ester is used as a key component in the synthesis of custom peptides for studying protein structures and functions. N'-(tert-Butoxycarbonyl)-N-(9-fluorenylmethyloxycarbonyl)-D-lysine pentafluorophenyl ester's ability to be selectively incorporated and later removed from peptides allows researchers to probe the effects of specific amino acid sequences on protein folding, stability, and interactions with other biomolecules.
Used in Pharmaceutical Development:
N'-(tert-Butoxycarbonyl)-N-(9-fluorenylmethyloxycarbonyl)-D-lysine pentafluorophenyl ester is employed in the pharmaceutical industry for the development of custom peptides with therapeutic potential. N'-(tert-Butoxycarbonyl)-N-(9-fluorenylmethyloxycarbonyl)-D-lysine pentafluorophenyl ester's versatility in peptide synthesis enables the creation of peptides with specific biological activities, such as enzyme inhibitors, receptor agonists or antagonists, or molecules with immunomodulatory properties. These custom peptides can be further optimized and tested for their efficacy and safety in treating various diseases and conditions.
Used in Drug Delivery Systems:
In drug delivery applications, N'-(tert-Butoxycarbonyl)-N-(9-fluorenylmethyloxycarbonyl)-D-lysine pentafluorophenyl ester can be used to synthesize peptides that serve as carriers or targeting moieties for drug molecules. N'-(tert-Butoxycarbonyl)-N-(9-fluorenylmethyloxycarbonyl)-D-lysine pentafluorophenyl ester's ability to be selectively incorporated and removed from peptides allows for the design of drug delivery systems with precise control over the release and targeting of therapeutic agents, potentially improving the efficacy and reducing the side effects of drug treatments.
Used in Bioconjugation:
N'-(tert-Butoxycarbonyl)-N-(9-fluorenylmethyloxycarbonyl)-D-lysine pentafluorophenyl ester is also used in the field of bioconjugation, where it can be employed to attach peptides to other biomolecules, such as proteins, nucleic acids, or nanoparticles. N'-(tert-Butoxycarbonyl)-N-(9-fluorenylmethyloxycarbonyl)-D-lysine pentafluorophenyl ester's reactivity and protection groups enable the formation of stable covalent bonds between peptides and other biomolecules, facilitating the development of conjugates with applications in diagnostics, therapeutics, or biosensing.

Check Digit Verification of cas no

The CAS Registry Mumber 133083-36-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,3,0,8 and 3 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 133083-36:
(8*1)+(7*3)+(6*3)+(5*0)+(4*8)+(3*3)+(2*3)+(1*6)=100
100 % 10 = 0
So 133083-36-0 is a valid CAS Registry Number.
InChI:InChI=1/C32H31F5N2O6/c1-32(2,3)45-30(41)38-15-9-8-14-22(29(40)44-28-26(36)24(34)23(33)25(35)27(28)37)39-31(42)43-16-21-19-12-6-4-10-17(19)18-11-5-7-13-20(18)21/h4-7,10-13,21-22H,8-9,14-16H2,1-3H3,(H,38,41)(H,39,42)/t22-/m1/s1

133083-36-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name (2,3,4,5,6-pentafluorophenyl) (2R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-6-[(2-methylpropan-2-yl)oxycarbonylamino]hexanoate

1.2 Other means of identification

Product number -
Other names Fmoc-D-Lys(Boc)-Opfp

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:133083-36-0 SDS

133083-36-0Downstream Products

133083-36-0Relevant articles and documents

Total Chemical Synthesis and Folding of All- l and All- d Variants of Oncogenic KRas(G12V)

Levinson, Adam M.,McGee, John H.,Roberts, Andrew G.,Creech, Gardner S.,Wang, Ting,Peterson, Michael T.,Hendrickson, Ronald C.,Verdine, Gregory L.,Danishefsky, Samuel J.

supporting information, p. 7632 - 7639 (2017/06/13)

The Ras proteins are essential GTPases involved in the regulation of cell proliferation and survival. Mutated oncogenic forms of Ras alter effector binding and innate GTPase activity, leading to deregulation of downstream signal transduction. Mutated forms of Ras are involved in approximately 30% of human cancers. Despite decades of effort to develop direct Ras inhibitors, Ras has long been considered "undruggable" due to its high affinity for GTP and its lack of hydrophobic binding pockets. Herein, we report a total chemical synthesis of all-l- and all-d-amino acid biotinylated variants of oncogenic mutant KRas(G12V). The protein is synthesized using Fmoc-based solid-phase peptide synthesis and assembled using combined native chemical ligation and isonitrile-mediated activation strategies. We demonstrate that both KRas(G12V) enantiomers can successfully fold and bind nucleotide substrates and binding partners with observable enantiodiscrimination. By demonstrating the functional competency of a mirror-image form of KRas bound to its corresponding enantiomeric nucleotide triphosphate, this study sets the stage for further biochemical studies with this material. In particular, this protein will enable mirror-image yeast surface display experiments to identify all-d peptide ligands for oncogenic KRas, providing a useful tool in the search for new therapeutics against this challenging disease target.

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