1331642-68-2 Usage
Description
(RS,Z)-2-dibutylamino-2-[2,7-dichloro-9-(4-chlorobenzylidene)-9H-fluoren-4-yl]ethanol, also known as Lumefantrine Impurity A, is a chemical compound derived from 5-Oxiranyl-2,7-dichlorofluorene (O846915), which is an intermediate in the synthesis of Lumefantrine. (RS,Z)-2-dibutylamino-2-[2,7-dichloro-9-(4-chlorobenzylidene)-9H-fluoren-4-yl]ethanol has a complex molecular structure with a fluorene core and various substituents, including dibutylamino and dichloro groups.
Uses
Used in Pharmaceutical Industry:
(RS,Z)-2-dibutylamino-2-[2,7-dichloro-9-(4-chlorobenzylidene)-9H-fluoren-4-yl]ethanol is used as an impurity in the synthesis of Lumefantrine for its role in the development and production of anti-malarial drugs. Lumefantrine is a key component in the treatment of malaria, and the presence of this impurity can affect the efficacy and safety of the final drug product. By understanding and controlling the presence of Lumefantrine Impurity A, pharmaceutical companies can ensure the quality and effectiveness of their anti-malarial medications.
Check Digit Verification of cas no
The CAS Registry Mumber 1331642-68-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,3,1,6,4 and 2 respectively; the second part has 2 digits, 6 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1331642-68:
(9*1)+(8*3)+(7*3)+(6*1)+(5*6)+(4*4)+(3*2)+(2*6)+(1*8)=132
132 % 10 = 2
So 1331642-68-2 is a valid CAS Registry Number.
1331642-68-2Relevant articles and documents
Lumefantrine isomer and preparation method thereof
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, (2018/01/12)
The invention discloses a lumefantrine isomer and a preparation method thereof, specifically a preparation method and uses of (RS,Z)-2-dibutylamino-2-[2,7-dichloro-9-(4-chlorobenzylidene)-9H-fluorene-4-yl]ethanol, wherein 2,7-dichlorofluorene-4-oxirane is used as a starting raw material and a selective ring-opening reaction, a substitution reaction, a deprotection reaction and a condensation reaction are performed to prepare the high-purity lumefantrine isomer. According to the present invention, the reaction conditions of the method are mild and simple, and the obtained lumefantrine isomer is the important impurity of the lumefantrine bulk drug, and is the impurity reference substance of the quality control.
