13322-40-2

Basic information

• Product Name: 1-(5-phenyl-1,3,4-thiadiazol-2-yl)-3-phenylurea
• Synonyms: 1-(5-phenyl-1,3,4-thiadiazol-2-yl)-3-phenylurea
• CAS NO: 13322-40-2
• Molecular Weight: 296.352
• Mol File: 13322-40-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-(5-phenyl-1,3,4-thiadiazol-2-yl)-3-phenylurea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(5-phenyl-1,3,4-thiadiazol-2-yl)-3-phenylurea(13322-40-2)
• EPA Substance Registry System: 1-(5-phenyl-1,3,4-thiadiazol-2-yl)-3-phenylurea(13322-40-2)

Safety Data

• Hazardous Substances Data: 13322-40-2(Hazardous Substances Data)

Upstream product

• 69378-06-9 2,6-diphenyl-[1,3,4]thiadiazolo[3,2-a][1,3,5]triazine-5,7-dione 
• 2002-03-1 2-amino-5-phenyl-1,3,4-thiadiazole 
• 103-71-9 phenyl isocyanate 
• 64-10-8 phenyl carbamate 
• 102367-68-0 2-amino-5-phenyl-1,3,4-thiadiazole hydrochloride 
• 65-85-0 benzoic acid 

Relevant articles and documents

Synthesis and in vitro evaluation of 1,3,4-thiadiazol-2-yl urea derivatives as novel AChE inhibitors

1,3,4-Thiadiazole and urea group were hybridized to form new molecular skeleton and 11 compounds were synthesized and evaluated as acetylcholinesterase (AChE) inhibitors. Most of them showed comparable effects in inhibition of AChE, especially compound 6b which exhibited activity with IC50 value 1.17 μM, as strong as galanthamine. This information offered by our research would be valuable for further investigation of structure-activity relationship (SAR) and useful in future research of AChE inhibitors.